VRTX - Vertex Pharmaceuticals Inc / Ma - Insider Stock Trading

Filing Date	T Date	Ticker	Sector	Ind	Industry	Owner	oSt	Rel	Title	T	TVal	Price	Qty	oc	Own	H
4/3/24 16:02	4/2/24	VRTX	Health	Drug	Pharmaceutical Preparations	Ambrose Kristen	MA	O	SVP,Chie	S	-101	419.00	0	-3	8	D
2/27/24 17:02	2/26/24	VRTX	Health	Drug	Pharmaceutical Preparations	Tatsis Ourania	MA	O	EVP,Chie	S	-151	425.70	0	-1	56	D
2/27/24 16:59	2/26/24	VRTX	Health	Drug	Pharmaceutical Preparations	Sachdev Amit	MA	O	EVP Chie	S	-1,279	425.70	-3	-5	63	D
2/27/24 16:44	2/26/24	VRTX	Health	Drug	Pharmaceutical Preparations	Atkinson Edward Morrow III	MA	O	EVP,Chie	S	-376	425.70	-1	-5	16	D
2/27/24 16:37	2/26/24	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,COO	S	-2,143	425.70	-5	-9	50	D
2/27/24 16:29	2/26/24	VRTX	Health	Drug	Pharmaceutical Preparations	Ambrose Kristen	MA	O	SVP,Chie	S	-376	425.70	-1	-10	8	D
2/27/24 16:24	2/26/24	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	S	-1,805	425.70	-4	-14	26	D
2/23/24 16:28	2/21/24	VRTX	Health	Drug	Pharmaceutical Preparations	Tatsis Ourania	MA	O	EVP,Chie	S	-152	421.77	0	-1	59	D
2/23/24 16:16	2/21/24	VRTX	Health	Drug	Pharmaceutical Preparations	Atkinson Edward Morrow III	MA	O	EVP,Chie	S	-507	421.77	-1	-6	19	D
2/23/24 16:12	2/21/24	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,COO	S	-1,520	421.77	-4	-6	60	D
2/23/24 16:10	2/21/24	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	S	-1,266	421.77	-3	-8	34	D
2/21/24 16:43	2/20/24	VRTX	Health	Drug	Pharmaceutical Preparations	Tatsis Ourania	MA	O	EVP,Chie	S	-202	420.79	0	-1	60	D
2/21/24 16:38	2/20/24	VRTX	Health	Drug	Pharmaceutical Preparations	Sachdev Amit	MA	O	EVP Chie	S	-1,790	420.79	-4	-6	71	D
2/21/24 16:23	2/20/24	VRTX	Health	Drug	Pharmaceutical Preparations	Atkinson Edward Morrow III	MA	O	EVP,Chie	S	-337	420.79	-1	-4	20	D
2/21/24 16:19	2/20/24	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,COO	S	-2,021	420.79	-5	-7	63	D
2/21/24 16:13	2/20/24	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	S	-1,684	420.79	-4	-10	37	D
2/16/24 16:07	2/14/24	VRTX	Health	Drug	Pharmaceutical Preparations	Leiden Jeffrey M	MA	DO	Exec CB	S.m	-3,777	419.10	-9	-33	18	D
2/14/24 16:04	2/12/24	VRTX	Health	Drug	Pharmaceutical Preparations	Leiden Jeffrey M	MA	DO	Exec CB	S.m	-1,423	419.42	-3	-11	27	D
2/13/24 17:15	2/12/24	VRTX	Health	Drug	Pharmaceutical Preparations	Sachdev Amit	MA	O	EVP Chie	S	-1,354	420.24	-3	-4	82	D
2/13/24 16:56	2/12/24	VRTX	Health	Drug	Pharmaceutical Preparations	Biller Jonathan	MA	O	EVP,GC	S	-728	418.77	-2	-9	18	D
2/13/24 16:54	2/12/24	VRTX	Health	Drug	Pharmaceutical Preparations	Atkinson Edward Morrow III	MA	O	EVP,Chie	S	-384	420.24	-1	-4	23	D
2/13/24 16:51	2/12/24	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,COO	S	-1,805	420.24	-4	-5	76	D
2/13/24 16:48	2/12/24	VRTX	Health	Drug	Pharmaceutical Preparations	Ambrose Kristen	MA	O	SVP,Chie	S	-577	420.24	-1	-12	10	D
2/13/24 16:46	2/12/24	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	S	-1,322	420.24	-3	-6	48	D
1/10/24 16:06	1/8/24	VRTX	Health	Drug	Pharmaceutical Preparations	Leiden Jeffrey M	MA	DO	Exec CB	S	-2,786	419.07	-7	-70	3	D
1/4/24 16:17	1/2/24	VRTX	Health	Drug	Pharmaceutical Preparations	Wagner Charles F Jr	MA	O	EVP,CFO	S	-1,215	405.00	-3	-6	44	D
12/19/23 16:15	12/15/23	VRTX	Health	Drug	Pharmaceutical Preparations	Kewalramani Reshma	MA	DO	CEO,P	M.d	3,116	181.83	17	19	109	D
12/19/23 16:15	12/15/23	VRTX	Health	Drug	Pharmaceutical Preparations	Kewalramani Reshma	MA	DO	CEO,P	S.d	-6,974	407.00	-17	-14	109	D
12/15/23 16:33	12/13/23	VRTX	Health	Drug	Pharmaceutical Preparations	Leiden Jeffrey M	MA	DO	Exec CB	S	-5,334	399.42	-13	-58	10	D
12/15/23 16:23	12/13/23	VRTX	Health	Drug	Pharmaceutical Preparations	Kewalramani Reshma	MA	DO	CEO,P	S	-2,024	397.00	-5	-4	109	D
12/15/23 16:20	12/13/23	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,COO	M.d	1,613	187.53	9	18	57	D
12/15/23 16:20	12/13/23	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,COO	S.d	-3,433	399.00	-9	-13	57	D
11/21/23 16:07	11/20/23	VRTX	Health	Drug	Pharmaceutical Preparations	Wagner Charles F Jr	MA	O	EVP,CFO	S	-1,050	349.88	-3	-6	47	D
11/17/23 16:16	11/15/23	VRTX	Health	Drug	Pharmaceutical Preparations	Sachdev Amit	MA	O	EVP Chie	S	-13	369.92	0	0	66	D
11/17/23 16:11	11/15/23	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	S	-7	369.92	0	0	32	D
11/16/23 16:15	11/14/23	VRTX	Health	Drug	Pharmaceutical Preparations	Bozic Carmen	MA	O	EVP,CMO	S	-2,152	380.82	-6	-16	29	D
11/15/23 16:16	11/13/23	VRTX	Health	Drug	Pharmaceutical Preparations	Kewalramani Reshma	MA	DO	CEO,P	S	-1,922	377.00	-5	-4	114	D
11/8/23 16:11	11/6/23	VRTX	Health	Drug	Pharmaceutical Preparations	Sachs Bruce I	MA	D		M.d	1,435	127.54	11	39	40	D
11/8/23 16:11	11/6/23	VRTX	Health	Drug	Pharmaceutical Preparations	Sachs Bruce I	MA	D		S.d	-4,331	385.00	-11	-22	40	D
11/2/23 16:07	10/31/23	VRTX	Health	Drug	Pharmaceutical Preparations	Bozic Carmen	MA	O	EVP,CMO	S	-2,011	355.92	-6	-14	35	D
10/19/23 16:18	10/17/23	VRTX	Health	Drug	Pharmaceutical Preparations	Bozic Carmen	MA	O	EVP,CMO	S	-2,109	373.25	-6	-12	41	D
10/19/23 16:13	10/17/23	VRTX	Health	Drug	Pharmaceutical Preparations	Bhatia Sangeeta N.	MA	D		S	-91	375.00	0	-6	4	D
10/18/23 16:17	10/16/23	VRTX	Health	Drug	Pharmaceutical Preparations	Leiden Jeffrey M	MA	DO	Exec CB	S	-4,848	374.00	-13	-36	23	D
10/11/23 16:14	10/6/23	VRTX	Health	Drug	Pharmaceutical Preparations	Bhatia Sangeeta N.	MA	D		S	-87	360.00	0	-6	4	D
10/5/23 16:30	10/3/23	VRTX	Health	Drug	Pharmaceutical Preparations	Bozic Carmen	MA	O	EVP,CMO	S	-1,951	345.28	-6	-11	46	D
10/3/23 16:07	10/2/23	VRTX	Health	Drug	Pharmaceutical Preparations	Biller Jonathan	MA	O	EVP,GC	S	-212	346.76	-1	-5	11	D
9/21/23 16:15	9/19/23	VRTX	Health	Drug	Pharmaceutical Preparations	Bozic Carmen	MA	O	EVP,CMO	S	-1,984	351.00	-6	-10	52	D
9/7/23 16:29	9/5/23	VRTX	Health	Drug	Pharmaceutical Preparations	Bozic Carmen	MA	O	EVP,CMO	S	-1,993	352.66	-6	-9	58	D
8/25/23 16:14	8/23/23	VRTX	Health	Drug	Pharmaceutical Preparations	Tatsis Ourania	MA	O	EVP,Chie	S	-888	355.00	-3	-5	49	D
8/14/23 16:09	8/10/23	VRTX	Health	Drug	Pharmaceutical Preparations	Kearney Terrence C	MA	D		M.d	1,275	127.54	10		7	D
8/14/23 16:09	8/10/23	VRTX	Health	Drug	Pharmaceutical Preparations	Kearney Terrence C	MA	D		S.d	-3,500	350.00	-10	-60	7	D
8/14/23 16:08	8/10/23	VRTX	Health	Drug	Pharmaceutical Preparations	Tatsis Ourania	MA	O	EVP,Chie	S	-1,988	345.79	-6	-10	51	D
8/14/23 16:05	8/10/23	VRTX	Health	Drug	Pharmaceutical Preparations	Sachdev Amit	MA	O	EVP,Chie	S	-3,511	350.00	-10	-13	66	D
8/11/23 16:05	8/9/23	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	S	-22	345.51	0	0	32	D
8/11/23 16:05	8/9/23	VRTX	Health	Drug	Pharmaceutical Preparations	Bhatia Sangeeta N.	MA	D		S	-84	345.51	0	-5	4	D
7/18/23 16:17	7/17/23	VRTX	Health	Drug	Pharmaceutical Preparations	Sachs Bruce I	MA	D		M.d	1,435	127.54	11	39	40	D
7/18/23 16:17	7/17/23	VRTX	Health	Drug	Pharmaceutical Preparations	Sachs Bruce I	MA	D		S.d	-4,013	356.75	-11	-22	40	D
7/18/23 16:13	7/17/23	VRTX	Health	Drug	Pharmaceutical Preparations	Kewalramani Reshma	MA	DO	CEO,P	S	-2,779	355.00	-8	-6	119	D
6/20/23 16:07	6/15/23	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,COO	M.d	1,613	187.53	9	18	57	D
6/20/23 16:07	6/15/23	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,COO	S.d	-3,002	349.00	-9	-13	57	D
6/1/23 16:16	5/30/23	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,COO	S	-27	329.82	0	0	57	D
6/1/23 16:12	5/30/23	VRTX	Health	Drug	Pharmaceutical Preparations	Ambrose Kristen	MA	O	SVP,Chie	S	-95	329.82	0	-4	7	D
5/9/23 16:15	5/5/23	VRTX	Health	Drug	Pharmaceutical Preparations	Sanna Bastiano	MA	O	EVP,Cell	S.m	-1,145	350.00	-3	-9	32	D
5/9/23 16:10	5/5/23	VRTX	Health	Drug	Pharmaceutical Preparations	Leiden Jeffrey M	MA	DO	Exec CB	S.m	-700	349.25	-2	-5	36	D
5/4/23 16:51	5/2/23	VRTX	Health	Drug	Pharmaceutical Preparations	Sanna Bastiano	MA	O	EVP,Cell	S.m	-1,544	350.71	-4	-11	35	D
5/4/23 16:50	5/2/23	VRTX	Health	Drug	Pharmaceutical Preparations	Leiden Jeffrey M	MA	DO	Exec CB	S.m	-3,835	349.98	-11	-22	38	D
5/3/23 16:44	5/2/23	VRTX	Health	Drug	Pharmaceutical Preparations	Bhatia Sangeeta N.	MA	D		S	-202	348.28	-1	-11	5	D
5/1/23 16:26	4/27/23	VRTX	Health	Drug	Pharmaceutical Preparations	Kewalramani Reshma	MA	DO	CEO,P	S	-1,125	339.08	-3	-3	127	D
4/14/23 16:19	4/12/23	VRTX	Health	Drug	Pharmaceutical Preparations	Sanna Bastiano	MA	O	EVP,Cell	S	-2,472	326.70	-8	-16	40	D
4/14/23 16:14	4/12/23	VRTX	Health	Drug	Pharmaceutical Preparations	Sachs Bruce I	MA	D		M.d	1,537	72.14	21	114	40	D
4/14/23 16:14	4/12/23	VRTX	Health	Drug	Pharmaceutical Preparations	Sachs Bruce I	MA	D		S.d	-6,959	326.73	-21	-35	40	D
4/6/23 16:23	4/4/23	VRTX	Health	Drug	Pharmaceutical Preparations	Sanna Bastiano	MA	O	EVP,Cell	S	-165	315.81	-1	-1	47	D
3/28/23 16:13	3/24/23	VRTX	Health	Drug	Pharmaceutical Preparations	Wagner Charles F Jr	MA	O	EVP,CFO	S	-540	305.38	-2	-3	50	D
3/21/23 16:21	3/17/23	VRTX	Health	Drug	Pharmaceutical Preparations	Wagner Charles F Jr	MA	O	EVP,CFO	S	-593	296.39	-2	-4	51	D
3/20/23 16:26	3/16/23	VRTX	Health	Drug	Pharmaceutical Preparations	Sanna Bastiano	MA	O	EVP,Cell	S	-825	300.59	-3	-5	49	D
3/14/23 16:22	3/10/23	VRTX	Health	Drug	Pharmaceutical Preparations	Wagner Charles F Jr	MA	O	EVP,CFO	S.m	-1,388	291.98	-5	-8	53	D
2/28/23 17:11	2/27/23	VRTX	Health	Drug	Pharmaceutical Preparations	Tatsis Ourania	MA	O	EVP,Chie	S	-102	287.48	0	-1	57	D
2/28/23 16:47	2/27/23	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,COO	S	-1,447	287.47	-5	-8	57	D
2/28/23 16:44	2/27/23	VRTX	Health	Drug	Pharmaceutical Preparations	Ambrose Kristen	MA	O	SVP,Chie	S	-347	287.55	-1	-14	7	D
2/28/23 16:40	2/27/23	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	S	-1,218	287.51	-4	-12	32	D
2/24/23 16:06	2/22/23	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,COO	S	-707	294.33	-2	-3	66	D
2/22/23 16:48	2/21/23	VRTX	Health	Drug	Pharmaceutical Preparations	Tatsis Ourania	MA	O	EVP,Chie	S	-141	293.75	0	-1	60	D
2/22/23 16:30	2/21/23	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,COO	S	-706	293.75	-2	-3	69	D
2/22/23 16:25	2/21/23	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	S	-1,176	293.77	-4	-9	40	D
2/16/23 16:18	2/14/23	VRTX	Health	Drug	Pharmaceutical Preparations	Tatsis Ourania	MA	O	EVP,Chie	S	-96	298.52	0	0	65	D
2/16/23 16:16	2/14/23	VRTX	Health	Drug	Pharmaceutical Preparations	Sanna Bastiano	MA	O	EVP,Cell	S	-655	300.40	-2	-4	60	D
2/16/23 16:14	2/14/23	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,COO	S	-1,911	298.68	-6	-8	76	D
2/16/23 16:11	2/14/23	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	S	-1,911	298.70	-6	-12	48	D
2/14/23 17:12	2/13/23	VRTX	Health	Drug	Pharmaceutical Preparations	Tatsis Ourania	MA	O	EVP,Chie	S	-82	298.99	0	0	66	D
2/14/23 17:08	2/13/23	VRTX	Health	Drug	Pharmaceutical Preparations	Sanna Bastiano	MA	O	EVP,Cell	S	-34	300.39	0	0	62	D
2/14/23 16:53	2/13/23	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,COO	S	-1,461	298.92	-5	-6	82	D
2/14/23 16:49	2/13/23	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	S	-1,434	298.90	-5	-8	54	D
2/8/23 16:53	2/6/23	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	M.d	245	187.53	1	2	69	D
2/8/23 16:53	2/6/23	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	S.d	-399	306.00	-1	-2	69	D
2/2/23 16:18	1/31/23	VRTX	Health	Drug	Pharmaceutical Preparations	Sanna Bastiano	MA	O	EVP,Cell	S	-34	325.00	0	0	38	D
2/2/23 16:14	1/31/23	VRTX	Health	Drug	Pharmaceutical Preparations	Sachs Bruce I	MA	D		M.d	87	72.14	1	3	41	D
2/2/23 16:14	1/31/23	VRTX	Health	Drug	Pharmaceutical Preparations	Sachs Bruce I	MA	D		S.d	-390	325.01	-1	-3	41	D
1/31/23 16:45	1/30/23	VRTX	Health	Drug	Pharmaceutical Preparations	Carney Lloyd	MA	D		S	-865	320.52	-3	-39	4	D
1/31/23 16:42	1/27/23	VRTX	Health	Drug	Pharmaceutical Preparations	Lee Yuchun	MA	D		M.d	103	72.14	1	320	2	D
1/31/23 16:42	1/27/23	VRTX	Health	Drug	Pharmaceutical Preparations	Lee Yuchun	MA	D		S.d	-460	322.03	-1	-43	2	D
1/27/23 16:18	1/25/23	VRTX	Health	Drug	Pharmaceutical Preparations	Lee Yuchun	MA	D		M.dm	577	72.14	8		2	D
1/27/23 16:18	1/25/23	VRTX	Health	Drug	Pharmaceutical Preparations	Lee Yuchun	MA	D		S.dm	-2,529	316.15	-8	-81	2	D
1/27/23 16:13	1/25/23	VRTX	Health	Drug	Pharmaceutical Preparations	Kewalramani Reshma	MA	DO	CEO,P	S	-3,151	315.05	-10	-10	90	D
1/25/23 16:08	1/23/23	VRTX	Health	Drug	Pharmaceutical Preparations	Lee Yuchun	MA	D		M.dm	442	72.14	6		2	D
1/25/23 16:08	1/23/23	VRTX	Health	Drug	Pharmaceutical Preparations	Lee Yuchun	MA	D		S.dm	-1,915	312.46	-6	-77	2	D
1/19/23 16:07	1/17/23	VRTX	Health	Drug	Pharmaceutical Preparations	Lee Yuchun	MA	D		M.dm	320	72.14	4		2	D
1/19/23 16:07	1/17/23	VRTX	Health	Drug	Pharmaceutical Preparations	Lee Yuchun	MA	D		S.dm	-1,386	312.04	-4	-70	2	D
11/17/22 16:08	11/15/22	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	S	-10	308.61	0	0	36	D
11/9/22 16:40	11/7/22	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	M.d	244	187.53	1	4	36	D
11/9/22 16:40	11/7/22	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	S.d	-395	303.04	-1	-3	36	D
11/3/22 16:05	11/2/22	VRTX	Health	Drug	Pharmaceutical Preparations	Sanna Bastiano	MA	O	EVP,Cell	S	-100	312.64	0	-1	38	D
10/26/22 16:05	10/24/22	VRTX	Health	Drug	Pharmaceutical Preparations	Bhatia Sangeeta N.	MA	D		S	-193	310.00	-1	-13	4	D
10/20/22 16:11	10/18/22	VRTX	Health	Drug	Pharmaceutical Preparations	Sanna Bastiano	MA	O	EVP,Cell	S	-538	300.31	-2	-4	39	D
8/17/22 17:40	8/15/22	VRTX	Health	Drug	Pharmaceutical Preparations	Kewalramani Reshma	MA	DO	CEO,P	S	-3,566	305.06	-12	-11	100	D
8/17/22 17:39	8/15/22	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,COO	M.d	1,022	155.57	7	17	45	D
8/17/22 17:39	8/15/22	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,COO	S.d	-6,739	303.93	-22	-33	45	D
8/17/22 17:36	8/15/22	VRTX	Health	Drug	Pharmaceutical Preparations	Liu Joy	MA	O	SVP,GC	S	-1,139	303.90	-4	-28	10	D
8/12/22 16:05	8/10/22	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,COO	M.d	10	155.57	0	0	61	D
8/12/22 16:05	8/10/22	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,COO	S.d	-54	300.41	0	0	61	D
8/12/22 16:05	8/10/22	VRTX	Health	Drug	Pharmaceutical Preparations	Liu Joy	MA	O	SVP,GC	S	-11	300.32	0	0	13	D
8/10/22 16:07	8/8/22	VRTX	Health	Drug	Pharmaceutical Preparations	Bhatia Sangeeta N.	MA	D		S	-182	293.03	-1	-12	5	D
8/10/22 16:06	8/9/22	VRTX	Health	Drug	Pharmaceutical Preparations	Liu Joy	MA	O	SVP,GC	S	-284	300.00	-1	-7	13	D
8/10/22 16:06	8/9/22	VRTX	Health	Drug	Pharmaceutical Preparations	Tatsis Ourania	MA	O	EVP,Chie	S	-419	298.97	-1	-3	46	D
8/10/22 16:06	8/9/22	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,COO	M.d	300	155.57	2	3	61	D
8/10/22 16:06	8/9/22	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,COO	S.d	-1,711	300.67	-6	-9	61	D
8/10/22 16:06	8/8/22	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	M.d	245	187.53	1	4	36	D
8/10/22 16:06	8/8/22	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	S.d	-381	292.54	-1	-3	36	D
8/2/22 16:16	7/29/22	VRTX	Health	Drug	Pharmaceutical Preparations	Bhatia Sangeeta N.	MA	D		S	-173	278.77	-1	-11	5	D
7/27/22 16:17	7/25/22	VRTX	Health	Drug	Pharmaceutical Preparations	Leiden Jeffrey M	MA	DO	Exec CB	M.d	5,494	91.05	60		3	D
7/27/22 16:17	7/25/22	VRTX	Health	Drug	Pharmaceutical Preparations	Leiden Jeffrey M	MA	DO	Exec CB	S.d	-37,164	281.38	-132	-98	3	D
7/21/22 16:48	7/19/22	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	M.d	3,097	174.33	18	97	36	D
7/21/22 16:48	7/19/22	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	S.d	-5,157	288.65	-18	-33	36	D
6/28/22 16:05	6/24/22	VRTX	Health	Drug	Pharmaceutical Preparations	Kewalramani Reshma	MA	DO	CEO,P	S	-3,405	291.30	-12	-10	111	D
5/18/22 16:22	5/16/22	VRTX	Health	Drug	Pharmaceutical Preparations	Sanna Bastiano	MA	O	EVP,Cell	S	-11	252.83	0	0	42	D
5/18/22 16:21	5/16/22	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,COO	S	-33	251.19	0	0	65	D
5/18/22 16:18	5/16/22	VRTX	Health	Drug	Pharmaceutical Preparations	Liu Joy	MA	O	SVP,GC	S	-34	252.88	0	-1	14	D
5/6/22 16:05	5/4/22	VRTX	Health	Drug	Pharmaceutical Preparations	Sanna Bastiano	MA	O	EVP,Cell	S	-10	275.09	0	0	42	D
5/4/22 17:21	5/2/22	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,COO	S	-81	263.98	0	0	65	D
5/4/22 17:10	5/2/22	VRTX	Health	Drug	Pharmaceutical Preparations	Sanna Bastiano	MA	O	EVP,Cell	S	-83	259.16	0	-1	42	D
5/4/22 17:09	5/2/22	VRTX	Health	Drug	Pharmaceutical Preparations	Bhatia Sangeeta N.	MA	D		S	-191	258.95	-1	-11	6	D
5/4/22 17:07	5/2/22	VRTX	Health	Drug	Pharmaceutical Preparations	Wagner Charles F Jr	MA	O	EVP,CFO	S	-89	258.83	0	-1	43	D
5/3/22 16:28	4/29/22	VRTX	Health	Drug	Pharmaceutical Preparations	Liu Joy	MA	O	SVP,GC	S	-33	275.41	0	-1	14	D
4/27/22 16:05	4/25/22	VRTX	Health	Drug	Pharmaceutical Preparations	Ambrose Kristen	MA	O	SVP,Chie	S	-88	269.55	0	-9	3	D
4/20/22 16:05	4/18/22	VRTX	Health	Drug	Pharmaceutical Preparations	Lee Yuchun	MA	D		M.d	163	81.54	2		2	D
4/20/22 16:05	4/18/22	VRTX	Health	Drug	Pharmaceutical Preparations	Lee Yuchun	MA	D		S.d	-568	284.23	-2	-52	2	D
4/18/22 16:05	4/14/22	VRTX	Health	Drug	Pharmaceutical Preparations	Lee Yuchun	MA	D		M.d	163	81.54	2		2	D
4/18/22 16:05	4/14/22	VRTX	Health	Drug	Pharmaceutical Preparations	Lee Yuchun	MA	D		S.d	-578	289.06	-2	-52	2	D
4/14/22 16:35	4/13/22	VRTX	Health	Drug	Pharmaceutical Preparations	Leiden Jeffrey M	MA	DO	Exec CB	S	-4,564	289.04	-16	-17	75	D
4/14/22 16:35	4/12/22	VRTX	Health	Drug	Pharmaceutical Preparations	Lee Yuchun	MA	D		M.dm	326	81.54	4		2	D
4/14/22 16:35	4/12/22	VRTX	Health	Drug	Pharmaceutical Preparations	Lee Yuchun	MA	D		S.dm	-1,137	284.27	-4	-68	2	D
4/12/22 16:07	4/8/22	VRTX	Health	Drug	Pharmaceutical Preparations	Lee Yuchun	MA	D		M.dm	326	81.54	4		2	D
4/12/22 16:07	4/8/22	VRTX	Health	Drug	Pharmaceutical Preparations	Lee Yuchun	MA	D		S.dm	-1,118	279.44	-4	-68	2	D
4/12/22 16:05	4/8/22	VRTX	Health	Drug	Pharmaceutical Preparations	Bhatia Sangeeta N.	MA	D		M.d	240	125.71	2	58	5	D
4/12/22 16:05	4/8/22	VRTX	Health	Drug	Pharmaceutical Preparations	Bhatia Sangeeta N.	MA	D		S.d	-534	280.20	-2	-27	5	D
4/12/22 16:05	4/8/22	VRTX	Health	Drug	Pharmaceutical Preparations	McGlynn Margaret G	MA	D		M.d	638	127.54	5		1	D
4/12/22 16:05	4/8/22	VRTX	Health	Drug	Pharmaceutical Preparations	McGlynn Margaret G	MA	D		S.d	-1,401	280.22	-5	-82	1	D
4/8/22 17:57	4/6/22	VRTX	Health	Drug	Pharmaceutical Preparations	Lee Yuchun	MA	D		M.dm	326	81.54	4		2	D
4/8/22 17:57	4/6/22	VRTX	Health	Drug	Pharmaceutical Preparations	Lee Yuchun	MA	D		S.dm	-1,093	273.24	-4	-68	2	D
4/8/22 16:34	4/7/22	VRTX	Health	Drug	Pharmaceutical Preparations	Sanna Bastiano	MA	O	EVP,Cell	S	-155	276.18	-1	-1	43	D
4/6/22 17:02	4/4/22	VRTX	Health	Drug	Pharmaceutical Preparations	Sanna Bastiano	MA	O	EVP,Cell	S.m	-1,021	274.10	-4	-8	43	D
4/6/22 16:59	4/4/22	VRTX	Health	Drug	Pharmaceutical Preparations	Lee Yuchun	MA	D		M.dm	326	81.54	4		2	D
4/6/22 16:59	4/4/22	VRTX	Health	Drug	Pharmaceutical Preparations	Lee Yuchun	MA	D		S.dm	-1,080	270.11	-4	-68	2	D
4/5/22 16:06	4/1/22	VRTX	Health	Drug	Pharmaceutical Preparations	Wagner Charles F Jr	MA	O	EVP,CFO	S	-684	264.76	-3	-6	44	D
4/4/22 16:05	3/31/22	VRTX	Health	Drug	Pharmaceutical Preparations	McGlynn Margaret G	MA	D		M.d	638	127.54	5		1	D
4/4/22 16:05	3/31/22	VRTX	Health	Drug	Pharmaceutical Preparations	McGlynn Margaret G	MA	D		S.d	-1,311	262.27	-5	-82	1	D
3/21/22 16:15	3/17/22	VRTX	Health	Drug	Pharmaceutical Preparations	Tatsis Ourania	MA	O	EVP,Chie	S	-709	250.11	-3	-6	47	D
3/21/22 16:12	3/17/22	VRTX	Health	Drug	Pharmaceutical Preparations	Wagner Charles F Jr	MA	O	EVP,CFO	S	-793	250.15	-3	-6	46	D
3/21/22 16:10	3/17/22	VRTX	Health	Drug	Pharmaceutical Preparations	Sanna Bastiano	MA	O	EVP,Cell	S	-531	250.06	-2	-4	48	D
2/28/22 17:27	2/25/22	VRTX	Health	Drug	Pharmaceutical Preparations	Tatsis Ourania	MA	O	EVP,Chie	S	-75	230.95	0	-1	50	D
2/22/22 17:03	2/18/22	VRTX	Health	Drug	Pharmaceutical Preparations	Tatsis Ourania	MA	O	EVP,Chie	S	-120	231.00	-1	-1	53	D
2/22/22 16:51	2/18/22	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	S	-996	230.97	-4	-8	50	D
2/16/22 16:05	2/14/22	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	S	-567	232.02	-2	-4	57	D
2/3/22 16:29	2/2/22	VRTX	Health	Drug	Pharmaceutical Preparations	Wagner Charles F Jr	MA	O	EVP,CFO	S	-736	250.07	-3	-5	57	D
2/3/22 16:26	2/2/22	VRTX	Health	Drug	Pharmaceutical Preparations	Sanna Bastiano	MA	O	EVP,Cell	S	-261	250.98	-1	-2	55	D
2/3/22 16:06	2/2/22	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	M.d	403	86.52	5	8	66	D
2/3/22 16:06	2/2/22	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	S.d	-1,172	251.47	-5	-7	66	D
2/1/22 16:09	1/28/22	VRTX	Health	Drug	Pharmaceutical Preparations	McGlynn Margaret G	MA	D		M.d	638	127.54	5		1	D
2/1/22 16:09	1/28/22	VRTX	Health	Drug	Pharmaceutical Preparations	McGlynn Margaret G	MA	D		S.d	-1,209	241.79	-5	-82	1	D
11/16/21 16:07	11/15/21	VRTX	Health	Drug	Pharmaceutical Preparations	Sachdev Amit	MA	O	EVP,Chie	S	-10	187.19	0	0	48	D
11/16/21 16:05	11/15/21	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,COO	S	-1	187.26	0	0	41	D
11/16/21 16:04	11/15/21	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	S	-6	187.22	0	0	34	D
8/23/21 08:30	8/19/21	VRTX	Health	Drug	Pharmaceutical Preparations	Kewalramani Reshma	MA	DO	CEO,P	P	1,956	195.65	10	16	74	D
8/4/21 16:05	8/2/21	VRTX	Health	Drug	Pharmaceutical Preparations	Sachs Bruce I	MA	D		P	2,969	197.91	15	57	41	D
6/4/21 16:03	6/2/21	VRTX	Health	Drug	Pharmaceutical Preparations	Bhatia Sangeeta N.	MA	D		S	-117	209.69	-1	-10	5	D
5/19/21 16:10	5/17/21	VRTX	Health	Drug	Pharmaceutical Preparations	Sanna Bastiano	MA	O	EVP,Cell	S	-24	216.34	0	0	34	D
5/19/21 16:08	5/17/21	VRTX	Health	Drug	Pharmaceutical Preparations	Sachdev Amit	MA	O	EVP,Chie	S	-10	216.35	0	0	48	D
5/19/21 16:06	5/17/21	VRTX	Health	Drug	Pharmaceutical Preparations	Liu Joy	MA	O	SVP,GC	S	-24	216.34	0	-1	8	D
5/19/21 16:04	5/17/21	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,Chie	S	-24	216.41	0	0	41	D
5/19/21 16:02	5/17/21	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	S	-17	216.36	0	0	34	D
5/5/21 21:23	5/3/21	VRTX	Health	Drug	Pharmaceutical Preparations	Sanna Bastiano	MA	O	EVP,Cell	S	-210	218.43	-1	-3	34	D
4/29/21 16:03	4/27/21	VRTX	Health	Drug	Pharmaceutical Preparations	Sachdev Amit	MA	O	EVP,Chie	M.d	336	86.52	4	9	48	D
4/29/21 16:03	4/27/21	VRTX	Health	Drug	Pharmaceutical Preparations	Sachdev Amit	MA	O	EVP,Chie	S.d	-839	216.06	-4	-7	48	D
4/7/21 16:04	4/5/21	VRTX	Health	Drug	Pharmaceutical Preparations	Sanna Bastiano	MA	O	EVP,Cell	S	-361	214.14	-2	-4	36	D
3/8/21 16:10	3/5/21	VRTX	Health	Drug	Pharmaceutical Preparations	Liu Joy	MA	O	SVP,GC	S	-1,078	209.69	-5	-38	8	D
3/2/21 16:07	3/1/21	VRTX	Health	Drug	Pharmaceutical Preparations	Silva Paul M	MA	O	SVP,Chie	S	-588	211.45	-3	-22	10	D
2/26/21 16:23	2/25/21	VRTX	Health	Drug	Pharmaceutical Preparations	Silva Paul M	MA	O	SVP,Chie	S	-231	213.47	-1	-7	15	D
2/26/21 16:20	2/25/21	VRTX	Health	Drug	Pharmaceutical Preparations	Sachdev Amit	MA	O	EVP,Chie	S	-765	213.42	-4	-7	48	D
2/26/21 16:18	2/25/21	VRTX	Health	Drug	Pharmaceutical Preparations	Parini Michael	MA	O	EVP,Chie	S	-646	213.38	-3	-9	31	D
2/26/21 16:07	2/25/21	VRTX	Health	Drug	Pharmaceutical Preparations	Arbuckle Stuart A	MA	O	EVP,Chie	S	-776	213.54	-4	-8	41	D
2/26/21 16:03	2/25/21	VRTX	Health	Drug	Pharmaceutical Preparations	Altshuler David	MA	O	EVP,Glob	S	-646	213.39	-3	-8	34	D

D	Derivative transaction in filing (usually option exercise)
M	Multiple transactions in filing; earliest reported transaction date and weighted average transaction price
A	Amended filing
E	Error detected in filing

S - Sale	Sale of securities on an exchange or to another person
S - Sale+OE	Sale of securities on an exchange or to another person (after option exercise)
F - Tax	Payment of exercise price or tax liability using portion of securities received from the company
P - Purchase	Purchase of securities on an exchange or from another person

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Filing Date

T Date

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Ind

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Owner

oSt

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oc

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r7d

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f1y