Insider Stock Trading

Filing Date	T Date	Ticker	Issuer	Inc	Sector	Ind	Industry	Owner	oSt	Rel	Title	T	TVal	Price	Qty	oc	Own	H
8/26/25 06:10	8/22/25	RNXT	Renovorx, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Bagai Shaun	CA	DO	CEO	P.m	9	0.9297	10	3	330	D
8/25/25 21:33	8/21/25	KALV	Kalvista Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Sweeny Nicole	MA	O	Chief Co	M.d	0	0.00	6	28	29	D
8/25/25 21:33	8/22/25	KALV	Kalvista Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Sweeny Nicole	MA	O	Chief Co	S.d	-25	13.22	-2	-6	29	D
8/25/25 21:13	8/21/25	ARDX	Ardelyx, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Williams Laura A	MA	O	Chief Pa	S	-37	5.93	-6	-2	396	D
8/25/25 21:12	8/21/25	ARDX	Ardelyx, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Renz Justin A	MA	O	CFO	S	-42	5.93	-7	-2	409	D
8/25/25 21:08	8/21/25	ARDX	Ardelyx, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Raab Michael	MA	DO	P,CEO	S	-271	5.93	-46	-3	1,528	D
8/25/25 21:03	8/21/25	ARDX	Ardelyx, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Grammer Elizabeth A	MA	O	See Rema	S	-35	5.93	-6	-2	306	D
8/25/25 21:02	8/21/25	ARDX	Ardelyx, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Foster Eric Duane	MA	O	Chief Co	S	-91	5.93	-15	-5	301	D
8/25/25 20:59	8/21/25	RYTM	Rhythm Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Shulman Joseph	MA	O	Chief Te	M.d	115	27.35	4	97	9	D
8/25/25 20:59	8/21/25	RYTM	Rhythm Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Shulman Joseph	MA	O	Chief Te	S.d	-419	100.07	-4	-33	9	D
8/25/25 19:46	8/21/25	KALV	Kalvista Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Yea Christopher	MA	O	Chief De	M.d	0	0.00	4	3	131	D
8/25/25 19:46	8/22/25	KALV	Kalvista Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Yea Christopher	MA	O	Chief De	S.d	-31	13.22	-2	-2	131	D
8/25/25 19:46	8/21/25	BYSI	Beyondspring Inc.		Health	Drug	Pharmaceutical Preparations	Decheng Capital China Life Sciences Usd Fund Iii, L.P.	CA	T		S.m	-10	1.77	-6	0	4,423	I
8/25/25 19:46	8/21/25	KALV	Kalvista Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Palleiko Benjamin L	MA	DO	CEO	M.d	0	0.00	23	6	387	D
8/25/25 19:46	8/22/25	KALV	Kalvista Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Palleiko Benjamin L	MA	DO	CEO	S.d	-145	13.22	-11	-3	387	D
8/25/25 19:45	8/21/25	KALV	Kalvista Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Audhya Paul K.	MA	O	Chief Me	M.d	0	0.00	6	6	120	D
8/25/25 19:45	8/22/25	KALV	Kalvista Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Audhya Paul K.	MA	O	Chief Me	S.d	-39	13.22	-3	-2	120	D
8/25/25 19:12	8/22/25	JNJ	Johnson & Johnson	NJ	Health	Drug	Pharmaceutical Preparations	Duato Joaquin	NJ	DO	CEO,CB	M.d	12,818	101.87	126	45	408	D
8/25/25 19:12	8/22/25	JNJ	Johnson & Johnson	NJ	Health	Drug	Pharmaceutical Preparations	Duato Joaquin	NJ	DO	CEO,CB	S.d	-22,549	179.21	-126	-24	408	D
8/25/25 17:04	8/21/25	NAMS	Newamsterdam Pharma Co N.V.	P7	Health	Drug	Pharmaceutical Preparations	Kastelein Johannes Jacob Pieter	P7	DO	Chief Sc	S.m	-2,472	24.72	-100	-59	69	I
8/25/25 16:27	8/22/25	AMRX	Amneal Pharmaceuticals, Inc.		Health	Drug	Pharmaceutical Preparations	Shah Nikita	NJ	O	EVP	S.m	-1,166	9.65	-121	-45	146	D
8/25/25 16:19	8/22/25	ANIP	Ani Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Davis Krista	MN	O	SVP,CHRO	S	-161	91.10	-2	-3	63	D
8/25/25 09:30	8/21/25	CALC	Calcimedica, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Roberts Eric W	CA	DOT	CHIEF BU	P	10	2.79	4	0	1,040	I
8/25/25 08:50	8/22/25	DVAX	Dynavax Technologies Corp	DE	Health	Drug	Pharmaceutical Preparations	Myers Scott Dunseth	CA	D		P	41	10.82	4	12	35	D
8/22/25 21:00	8/20/25	ROIV	Roivant Sciences Ltd.	D0	Health	Drug	Pharmaceutical Preparations	Venker Eric	X0	O	P,Immuno	M.d	385	3.85	100	6	1,654	D
8/22/25 21:00	8/20/25	ROIV	Roivant Sciences Ltd.	D0	Health	Drug	Pharmaceutical Preparations	Venker Eric	X0	O	P,Immuno	S.d	-1,172	11.72	-100	-6	1,654	D
8/22/25 20:49	8/21/25	DVAX	Dynavax Technologies Corp	DE	Health	Drug	Pharmaceutical Preparations	Deep Track Biotechnology Master Fund, Ltd.	E9	T		S.m	-22,352	10.82	-2,065	-12	15,726	D
8/22/25 19:07	8/21/25	SKYE	Skye Bioscience, Inc.	NV	Health	Drug	Pharmaceutical Preparations	Schwab Andrew J.	CA	DT		S.m	-801	3.46	-231	-2	9,682	I
8/22/25 19:05	8/21/25	SKYE	Skye Bioscience, Inc.	NV	Health	Drug	Pharmaceutical Preparations	5Am Partners Vii, LLC	CA	T		S.m	-801	3.46	-231	-2	9,682	I
8/22/25 18:10	8/20/25	ANIP	Ani Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Shanmugam Muthusamy	MN	DO	HEAD OF	S.m	-9,036	90.36	-100	-16	530	I
8/22/25 17:20	8/22/25	RNA	Avidity Biosciences, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Hughes Steven George	CA	O	Chief Me	M.d	22	10.16	2	6	39	D
8/22/25 17:20	8/22/25	RNA	Avidity Biosciences, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Hughes Steven George	CA	O	Chief Me	S.d	-102	46.40	-2	-5	39	D
8/22/25 16:58	8/21/25	BBIO	Bridgebio Pharma, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Trimarchi Thomas	CA	O	P,CFO	S	-2,090	49.48	-42	-9	421	D
8/22/25 16:46	8/20/25	BBIO	Bridgebio Pharma, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Kumar Neil	CA	DO	CEO	S	-1,277	48.82	-26	0	5,857	D
8/22/25 16:38	8/20/25	AMRX	Amneal Pharmaceuticals, Inc.		Health	Drug	Pharmaceutical Preparations	Boyer Andrew S	NJ	O	EVP	M.d	481	2.75	175		152	D
8/22/25 16:38	8/20/25	AMRX	Amneal Pharmaceuticals, Inc.		Health	Drug	Pharmaceutical Preparations	Boyer Andrew S	NJ	O	EVP	S.d	-2,619	9.38	-279	-65	152	D
8/22/25 16:32	8/21/25	UTHR	United Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	Mahon Paul A	MD	O	EVP,GC	M.d	1,490	135.42	11	43	37	D
8/22/25 16:32	8/21/25	UTHR	United Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	Mahon Paul A	MD	O	EVP,GC	S.d	-3,396	308.75	-11	-23	37	D
8/22/25 16:30	8/21/25	SPRY	Ars Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Lowenthal Richard E	CA	DOT	P,CEO	S	-724	14.49	-50	0	11,303	I
8/22/25 16:30	8/21/25	SPRY	Ars Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Scott Kathleen D.	CA	O	CFO	M.d	19	1.50	13	216	18	D
8/22/25 16:30	8/21/25	SPRY	Ars Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Scott Kathleen D.	CA	O	CFO	S.d	-188	15.00	-13	-41	18	D
8/22/25 16:19	8/21/25	BHC	Bausch Health Companies Inc.	NJ	Health	Drug	Pharmaceutical Preparations	Lee Frank D.	NJ	D		S	-122	7.66	-16	-18	74	D
8/22/25 16:07	8/21/25	LYEL	Lyell Immunopharma, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Seely Lynn	CA	DO	P,CEO	S	-77	10.54	-7	-10	68	D
8/22/25 16:06	8/21/25	LYEL	Lyell Immunopharma, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Hill Stephen J.	CA	O	COO	S	-11	10.54	-1	-6	16	D
8/22/25 16:03	8/21/25	LYEL	Lyell Immunopharma, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Newton Charles W.	CA	O	CFO	S	-15	10.54	-1	-5	25	D
8/22/25 16:02	8/21/25	LYEL	Lyell Immunopharma, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Lee Gary K.	CA	O	Chief Sc	S	-15	10.54	-1	-9	16	D
8/22/25 13:27	8/22/25	PRGO	Perrigo Co Plc	L2	Health	Drug	Pharmaceutical Preparations	Willis Robert	MI	O	EVP,CHRO	P	36	24.10	1	4	42	D
8/22/25 06:10	8/20/25	DRRX	Durect Corp	DE	Health	Drug	Pharmaceutical Preparations	Asen R Scott	NY	T		P.m	387	1.89	204	6	3,637	M
8/21/25 21:32	8/19/25	ARQT	Arcutis Biotherapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Burnett Patrick	CA	O	See Rema	S.m	-66	15.82	-4	-4	105	D
8/21/25 21:05	8/19/25	NKTR	Nektar Therapeutics	DE	Health	Drug	Pharmaceutical Preparations	Zalevsky Jonathan	CA	O	Chief R,	S.d	-19	26.59	-1	-4	20	D
8/21/25 21:04	8/19/25	NKTR	Nektar Therapeutics	DE	Health	Drug	Pharmaceutical Preparations	Wilson Mark Andrew	CA	O	GC	S.d	-18	26.59	-1	-3	20	D
8/21/25 21:03	8/19/25	NKTR	Nektar Therapeutics	DE	Health	Drug	Pharmaceutical Preparations	Robin Howard W	CA	DO	P,CEO	S.d	-42	26.59	-2	-2	69	D
8/21/25 20:44	8/21/25	CLNN	Clene Inc.	DE	Health	Drug	Pharmaceutical Preparations	General Resonance LLC	UT	T		S	-18	5.34	-3	0	705	D
8/21/25 18:48	8/20/25	ELVN	Enliven Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Kintz Samuel	CO	DO	P,CEO	S.a	-30	20.00	-2	0	928	I
8/21/25 18:46	8/19/25	ELVN	Enliven Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Lyssikatos Joseph P	CO	O	CHIEF SC	S.m	-248	19.86	-13	-1	940	I
8/21/25 17:44	8/21/25	MDGL	Madrigal Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Sibold William John	PA	DO	P,CEO	S	-3,048	400.18	-8	-6	110	D
8/21/25 17:36	8/19/25	SPRY	Ars Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Tanimoto Sarina	CA	OT	CHIEF ME	S.m	-704	14.08	-50	0	11,353	I
8/21/25 17:22	8/21/25	TNXP	Tonix Pharmaceuticals Holding Corp.	NV	Health	Drug	Pharmaceutical Preparations	Taylor Carolyn E.	NJ	D		P	15	36.03	0	New	0	D
8/21/25 17:07	8/20/25	INSM	Insmed Inc	VA	Health	Drug	Pharmaceutical Preparations	Sharoky Melvin Md	NJ	D		S	-1,295	129.50	-10	-3	307	D
8/21/25 17:05	8/19/25	INSM	Insmed Inc	VA	Health	Drug	Pharmaceutical Preparations	Adsett Roger	NJ	O	COO	S	-3,190	127.58	-25	-19	106	D
8/21/25 17:00	8/19/25	CYRX	Cryoport, Inc.	NV	Health	Drug	Pharmaceutical Preparations	Stefanovich Robert	TN	O	CFO	M.d	80	3.07	26	14	207	D
8/21/25 17:00	8/19/25	CYRX	Cryoport, Inc.	NV	Health	Drug	Pharmaceutical Preparations	Stefanovich Robert	TN	O	CFO	S.d	-81	8.67	-9	-4	207	D
8/21/25 16:30	8/19/25	LQDA	Liquidia Corp	DE	Health	Drug	Pharmaceutical Preparations	Horobin Joanna	NC	D		S	-136	27.17	-5	-13	34	D
8/21/25 16:30	8/20/25	CRNX	Crinetics Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Pizzuti Dana	CA	O	Chief Me	S	-189	29.18	-6	-9	66	D
8/21/25 16:19	8/19/25	MGNX	Macrogenics Inc	DE	Health	Drug	Pharmaceutical Preparations	Heiden William K	MD	D		P.m	151	1.51	100	909	111	D
8/21/25 16:15	8/19/25	TNGX	Tango Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Third Rock Ventures Iv, L.P.	MA	T		S	-7,713	7.01	-1,100	-7	15,759	D
8/21/25 16:05	8/20/25	SION	Sionna Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Cloonan Michael	MA	DO	P,CEO	M.d	153	6.11	25	5	547	D
8/21/25 16:05	8/20/25	SION	Sionna Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Cloonan Michael	MA	DO	P,CEO	S.d	-569	22.75	-25	-4	547	D
8/21/25 16:04	8/19/25	SION	Sionna Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Ridloff Elena	MA	O	CFO,Head	S.m	-1,124	21.62	-52	-42	72	D
8/21/25 12:00	8/19/25	CALC	Calcimedica, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Roberts Eric W	CA	DOT	CHIEF BU	P.dm	8	2.74	3	0	1,037	M
8/21/25 12:00	8/20/25	CALC	Calcimedica, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Roberts Eric W	CA	DOT	CHIEF BU	M.d	23	1.53	15	1	1,037	M
8/21/25 12:00	8/19/25	CALC	Calcimedica, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Hebbar Sudarshan	CA	O	Chief Me	P	27	2.82	10	18	62	D
8/20/25 18:35	8/18/25	BYSI	Beyondspring Inc.		Health	Drug	Pharmaceutical Preparations	Decheng Capital China Life Sciences Usd Fund Iii, L.P.	CA	T		S.m	-109	1.99	-55	-1	4,429	I
8/20/25 18:14	8/18/25	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	Bennett C Frank	CA	O	EVP,Chie	M.d	326	32.60	10	12	93	D
8/20/25 18:14	8/18/25	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	Bennett C Frank	CA	O	EVP,Chie	S.d	-440	43.98	-10	-10	93	D
8/20/25 18:12	8/18/25	MDGL	Madrigal Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Baker Bros. Advisors LP	NY	D		P.m	36,941	380.58	97	5	1,948	I
8/20/25 18:09	8/18/25	MDGL	Madrigal Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Baker Bros. Advisors LP	NY	D		P	24,980	364.04	69	4	1,859	I
8/20/25 17:14	8/19/25	ETON	Eton Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Gruber James R.	IL	O	CFO	S.m	-674	16.15	-42	-17	205	D
8/20/25 17:13	8/18/25	SER	Serina Therapeutics, Inc.	AL	Health	Drug	Pharmaceutical Preparations	Moreadith Randall	AL	O	Chief Sc	M.dm	0	0.0600	4		0	D
8/20/25 17:13	8/18/25	SER	Serina Therapeutics, Inc.	AL	Health	Drug	Pharmaceutical Preparations	Moreadith Randall	AL	O	Chief Sc	S.dm	-22	5.18	-4	-100	0	D
8/20/25 17:00	8/18/25	RCKT	Rocket Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Militello John	NJ	O	See Rema	S.m	-3	3.04	-1	-2	56	D
8/20/25 17:00	8/18/25	RCKT	Rocket Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Schwartz Jonathan David	NJ	O	See Rema	S.m	-8	3.04	-2	-1	222	D
8/20/25 17:00	8/18/25	RCKT	Rocket Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Wilson Martin	NJ	O	GC	S.m	-5	3.04	-2	-1	135	D
8/20/25 16:57	8/18/25	COLL	Collegium Pharmaceutical, Inc	VA	Health	Drug	Pharmaceutical Preparations	Dreyer Scott	MA	O	EVP,Chie	M.d	350	21.34	16	19	104	D
8/20/25 16:57	8/18/25	COLL	Collegium Pharmaceutical, Inc	VA	Health	Drug	Pharmaceutical Preparations	Dreyer Scott	MA	O	EVP,Chie	S.d	-626	38.21	-16	-14	104	D
8/20/25 16:42	8/18/25	ANIP	Ani Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Thoma Jeanne	MN	D		S	-1,920	89.15	-22	-48	23	D
8/20/25 16:41	8/20/25	ANIP	Ani Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Pera Antonio R	MN	D		S	-486	89.73	-5	-15	30	D
8/20/25 16:38	8/19/25	ZVRA	Zevra Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Bode John B	FL	D		P	46	9.17	5	13	45	D
8/20/25 16:36	8/18/25	KNSA	Kiniksa Pharmaceuticals International, Plc	X0	Health	Drug	Pharmaceutical Preparations	Tessari Eben	X0	O	COO	M.d	57	8.83	7	19	40	D
8/20/25 16:36	8/18/25	KNSA	Kiniksa Pharmaceuticals International, Plc	X0	Health	Drug	Pharmaceutical Preparations	Tessari Eben	X0	O	COO	S.d	-547	33.77	-16	-29	40	D
8/20/25 16:36	8/18/25	ELVN	Enliven Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Kintz Samuel	CO	DO	P,CEO	S.m	-220	20.02	-11	-1	929	I
8/20/25 16:28	8/18/25	INSM	Insmed Inc	VA	Health	Drug	Pharmaceutical Preparations	Lewis William	NJ	DO	Chair,CE	M.d	74	10.85	7	1	588	I
8/20/25 16:28	8/18/25	INSM	Insmed Inc	VA	Health	Drug	Pharmaceutical Preparations	Lewis William	NJ	DO	Chair,CE	S.d	-881	128.40	-7	-1	588	I
8/20/25 16:15	8/20/25	TNXP	Tonix Pharmaceuticals Holding Corp.	NV	Health	Drug	Pharmaceutical Preparations	Treco James	NJ	D		P	9	36.00	0	New	0	D
8/20/25 16:13	8/18/25	STOK	Stoke Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Ticho Barry	MA	O	Chief Me	S	-51	18.24	-3	-10	24	D
8/20/25 16:12	8/18/25	STOK	Stoke Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Kaye Edward M. Md	MA	D		S	-221	18.24	-12	-7	153	D
8/20/25 16:11	8/18/25	STOK	Stoke Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Allan Jonathan	MA	O	GC,Corp	S	-31	18.24	-2	-7	24	D
8/20/25 16:04	8/19/25	GOSS	Gossamer Bio, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Milligan Sandra	CA	D		P	50	1.92	26	81	58	D
8/20/25 16:02	8/18/25	ALXO	Alx Oncology Holdings Inc	DE	Health	Drug	Pharmaceutical Preparations	Shantharam Harish	CA	O	CFO	P	58	0.7787	75	New	75	D
8/20/25 16:01	8/15/25	ARCT	Arcturus Therapeutics Holdings Inc.	DE	Health	Drug	Pharmaceutical Preparations	Sassine Andy	CA	DO	CFO	P.a	20	16.56	1	1	222	D
8/20/25 08:11	8/18/25	PRGO	Perrigo Co Plc	L2	Health	Drug	Pharmaceutical Preparations	Parker Geoffrey M.	MI	D		P.a	100	22.97	4	7	65	I
8/19/25 21:32	8/15/25	AKRO	Akero Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Gangloff Scott A.	CA	O	CTO	M.d	51	19.62	3	11	26	D
8/19/25 20:00	8/15/25	WVE	Wave Life Sciences Ltd.	U0	Health	Drug	Pharmaceutical Preparations	Tan Aik Na	MA	D		M.d	192	9.13	21	108	40	D
8/19/25 20:00	8/15/25	WVE	Wave Life Sciences Ltd.	U0	Health	Drug	Pharmaceutical Preparations	Tan Aik Na	MA	D		S.d	-194	9.25	-21	-34	40	D
8/19/25 19:40	8/18/25	BBIO	Bridgebio Pharma, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Trimarchi Thomas	CA	O	P,CFO	S	-872	50.23	-17	-4	463	D
8/19/25 19:40	8/15/25	DAWN	Day One Biopharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	York Charles N II	CA	O	COO,CFO	M.d	0	0.00	17	6	278	D
8/19/25 19:40	8/18/25	DAWN	Day One Biopharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	York Charles N II	CA	O	COO,CFO	S.d	-28	6.77	-4	-1	278	D
8/19/25 19:38	8/16/25	BBIO	Bridgebio Pharma, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Kumar Neil	CA	DO	CEO	M.d	0	0.00	65	1	5,883	D
8/19/25 19:38	8/15/25	DAWN	Day One Biopharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Dubow Adam	CA	O	GC,Secre	M.d	0	0.00	12	28	55	D
8/19/25 19:38	8/18/25	DAWN	Day One Biopharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Dubow Adam	CA	O	GC,Secre	S.d	-30	6.77	-4	-7	55	D
8/19/25 19:37	8/15/25	DAWN	Day One Biopharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Bender Jeremy	CA	DO	CEO	M.d	0	0.00	32	2	1,770	D
8/19/25 19:37	8/18/25	DAWN	Day One Biopharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Bender Jeremy	CA	DO	CEO	S.d	-109	6.77	-16	-1	1,770	D
8/19/25 19:36	8/15/25	DAWN	Day One Biopharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Merendino Lauren	CA	O	Chief Co	M.d	0	0.00	11	34	42	D
8/19/25 19:36	8/18/25	DAWN	Day One Biopharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Merendino Lauren	CA	O	Chief Co	S.d	-25	6.77	-4	-8	42	D
8/19/25 18:00	8/18/25	ACAD	Acadia Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Schneyer Mark C.	CA	O	EVP,CFO	S	-554	25.18	-22	-35	40	D
8/19/25 17:28	8/18/25	ALNY	Alnylam Pharmaceuticals, Inc.		Health	Drug	Pharmaceutical Preparations	Garg Pushkal	MA	O	EVP Chie	S.m	-1,300	455.89	-3	-12	21	D
8/19/25 17:28	8/18/25	ALNY	Alnylam Pharmaceuticals, Inc.		Health	Drug	Pharmaceutical Preparations	Tanguler Tolga	MA	O	EVP,Chie	S	-633	453.27	-1	-5	29	D
8/19/25 17:27	8/18/25	ALNY	Alnylam Pharmaceuticals, Inc.		Health	Drug	Pharmaceutical Preparations	Poulton Jeffrey V.	MA	O	EVP,CFO	S	-1,031	453.27	-2	-4	50	D
8/19/25 17:27	8/18/25	ALNY	Alnylam Pharmaceuticals, Inc.		Health	Drug	Pharmaceutical Preparations	Greenstreet Yvonne	MA	DO	CEO	S	-3,163	453.27	-7	-11	57	D
8/19/25 17:26	8/18/25	ALNY	Alnylam Pharmaceuticals, Inc.		Health	Drug	Pharmaceutical Preparations	Fitzgerald Kevin Joseph	MA	O	CSO,EVP,	S	-633	453.27	-1	-6	23	D
8/19/25 17:26	8/18/25	ALNY	Alnylam Pharmaceuticals, Inc.		Health	Drug	Pharmaceutical Preparations	Bonney Michael W	MA	D		M.d	790	70.20	11	118	21	D
8/19/25 17:26	8/18/25	ALNY	Alnylam Pharmaceuticals, Inc.		Health	Drug	Pharmaceutical Preparations	Bonney Michael W	MA	D		S.d	-5,063	450.00	-11	-35	21	D
8/19/25 17:10	8/15/25	COLL	Collegium Pharmaceutical, Inc	VA	Health	Drug	Pharmaceutical Preparations	Santini Gino	MA	D		M.d	202	13.45	15	19	95	D
8/19/25 17:10	8/15/25	COLL	Collegium Pharmaceutical, Inc	VA	Health	Drug	Pharmaceutical Preparations	Santini Gino	MA	D		S.d	-201	37.19	-5	-5	95	D
8/19/25 17:02	8/18/25	SEPN	Septerna, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Klein Uwe	CA	O	SVP,Biol	M.d	94	4.10	23	22	128	D
8/19/25 16:40	8/18/25	APLS	Apellis Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Watson David O.	MA	O	GC	S	-139	27.80	-5	-2	204	D
8/19/25 16:40	8/15/25	ZLAB	Zai Lab Ltd	E9	Health	Drug	Pharmaceutical Preparations	Smiley Joshua L	MA	O	See Rema	M.d	0	0.00	16	26	77	D
8/19/25 16:40	8/18/25	ZLAB	Zai Lab Ltd	E9	Health	Drug	Pharmaceutical Preparations	Smiley Joshua L	MA	O	See Rema	S.d	-241	36.24	-7	-8	77	D
8/19/25 16:40	8/15/25	ZLAB	Zai Lab Ltd	E9	Health	Drug	Pharmaceutical Preparations	Edmondson Frazor Titus III	MA	O	GC	M.d	0	0.00	5	13	42	D
8/19/25 16:40	8/18/25	ZLAB	Zai Lab Ltd	E9	Health	Drug	Pharmaceutical Preparations	Edmondson Frazor Titus III	MA	O	GC	S.d	-68	36.24	-2	-4	42	D
8/19/25 16:37	8/19/25	CYTK	Cytokinetics Inc		Health	Drug	Pharmaceutical Preparations	Malik Fady Ibraham	CA	O	EVP Rese	M.d	21	10.60	2	1	141	D
8/19/25 16:37	8/19/25	CYTK	Cytokinetics Inc		Health	Drug	Pharmaceutical Preparations	Malik Fady Ibraham	CA	O	EVP Rese	S.d	-77	38.31	-2	-1	141	D
8/19/25 16:30	8/15/25	NUVL	Nuvalent, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Porter James Richard	MA	DO	P,CEO	M.d	511	18.93	27	12	249	D
8/19/25 16:30	8/15/25	NUVL	Nuvalent, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Porter James Richard	MA	DO	P,CEO	S.d	-2,036	75.42	-27	-10	249	D
8/19/25 16:30	8/15/25	LQDA	Liquidia Corp	DE	Health	Drug	Pharmaceutical Preparations	Kaseta Michael	NC	O	CFO,COO	S	-524	26.18	-20	-5	356	D
8/19/25 16:27	8/17/25	KALV	Kalvista Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Yea Christopher	MA	O	Chief De	M.d	0	0.00	4	3	129	D
8/19/25 16:27	8/18/25	KALV	Kalvista Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Yea Christopher	MA	O	Chief De	S.d	-35	13.19	-3	-2	129	D
8/19/25 16:26	8/17/25	KALV	Kalvista Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Audhya Paul K.	MA	O	Chief Me	M.d	0	0.00	6	6	117	D
8/19/25 16:26	8/18/25	KALV	Kalvista Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Audhya Paul K.	MA	O	Chief Me	S.d	-39	13.19	-3	-2	117	D
8/19/25 16:26	8/17/25	KALV	Kalvista Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Palleiko Benjamin L	MA	DO	CEO	M.d	0	0.00	9	3	375	D
8/19/25 16:26	8/18/25	KALV	Kalvista Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Palleiko Benjamin L	MA	DO	CEO	S.d	-58	13.19	-4	-1	375	D
8/19/25 16:15	8/15/25	HRMY	Harmony Biosciences Holdings, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Kapadia Sandip	PA	O	CFO	S	-787	36.50	-22	-100	0	D
8/19/25 16:12	8/15/25	ALXO	Alx Oncology Holdings Inc	DE	Health	Drug	Pharmaceutical Preparations	Pinto Shelly	CA	O	SVP,Fina	S	0	0.6404	-1	-1	89	D
8/19/25 16:09	8/15/25	ALXO	Alx Oncology Holdings Inc	DE	Health	Drug	Pharmaceutical Preparations	Lettmann Jason	CA	DO	CEO	S	-2	0.6404	-2	-1	213	D
8/19/25 16:08	8/15/25	MCRB	Seres Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Shaff Eric D.	MA	D		M.d	0	0.00	1	7	11	D
8/19/25 16:08	8/18/25	MCRB	Seres Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Shaff Eric D.	MA	D		S.d	-4	16.65	0	-2	11	D
8/19/25 16:07	8/15/25	MCRB	Seres Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Desrosier Thomas	MA	O	See Rema	M.d	0	0.00	0	3	7	D
8/19/25 16:07	8/18/25	MCRB	Seres Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Desrosier Thomas	MA	O	See Rema	S.d	-1	16.65	0	-1	7	D
8/19/25 16:07	8/15/25	MCRB	Seres Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Henn Matthew R	MA	O	See Rema	M.d	0	0.00	0	6	5	D
8/19/25 16:07	8/18/25	MCRB	Seres Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Henn Matthew R	MA	O	See Rema	S.d	-1	16.65	0	-2	5	D
8/19/25 16:06	8/15/25	MCRB	Seres Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Young Teresa L.	MA	O	See Rema	M.d	0	0.00	0	5	5	D
8/19/25 16:06	8/18/25	MCRB	Seres Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Young Teresa L.	MA	O	See Rema	S.d	-1	16.65	0	-1	5	D
8/19/25 16:05	8/15/25	ARCT	Arcturus Therapeutics Holdings Inc.	DE	Health	Drug	Pharmaceutical Preparations	Sassine Andy	CA	DO	CFO	P	20	16.56	1	1	222	D
8/19/25 16:01	8/18/25	COYA	Coya Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Goldstein Dov A Md	TX	D		M.d	19	1.09	18	176	28	D
8/19/25 13:45	8/15/25	CALC	Calcimedica, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Roberts Eric W	CA	DOT	CHIEF BU	P	15	2.90	5	1	1,019	I
8/19/25 10:56	8/18/25	PRGO	Perrigo Co Plc	L2	Health	Drug	Pharmaceutical Preparations	Parker Geoffrey M.	MI	D		P	100	22.97	4	7	65	D
8/19/25 10:41	8/18/25	PRGO	Perrigo Co Plc	L2	Health	Drug	Pharmaceutical Preparations	Bezerra Eduardo Guarita	MI	O	EVP,CFO	P	68	22.74	3	7	49	D
8/18/25 20:25	8/14/25	STOK	Stoke Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Ticho Barry	MA	O	Chief Me	M.d	0	0.00	10	60	27	D
8/18/25 20:24	8/14/25	STOK	Stoke Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Allan Jonathan	MA	O	GC,Corp	M.d	0	0.00	6	31	26	D
8/18/25 20:23	8/14/25	STOK	Stoke Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Kaye Edward M. Md	MA	D		M.d	0	0.00	26	19	166	D
8/18/25 18:19	8/15/25	JNJ	Johnson & Johnson	NJ	Health	Drug	Pharmaceutical Preparations	Wolk Joseph J	NJ	O	EVP,CFO	M.d	1,713	101.87	17	25	85	D
8/18/25 18:19	8/15/25	JNJ	Johnson & Johnson	NJ	Health	Drug	Pharmaceutical Preparations	Wolk Joseph J	NJ	O	EVP,CFO	S.d	-2,976	176.91	-17	-17	85	D
8/18/25 18:00	8/14/25	ATAI	Atai Life Sciences N.V.	P7	Health	Drug	Pharmaceutical Preparations	Apeiron Investment Group Ltd.	O1	T		P	19,000	2.19	8,676	20	52,845	I
8/18/25 17:33	8/18/25	MDGL	Madrigal Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Kelley Shannon T	PA	O	GC	S	-480	367.81	-1	-12	9	D
8/18/25 17:23	8/18/25	ANIP	Ani Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Leonard Matthew J	MN	D		S	-612	88.17	-7	-42	9	D
8/18/25 17:14	8/15/25	RAPP	Rapport Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Bredt David	MA	O	Chief Sc	S	-127	15.00	-9	-2	427	D
8/18/25 17:02	8/14/25	SNDX	Syndax Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Podlesak Dennis	NY	D		M.dm	415	7.20	58	43	192	D
8/18/25 17:02	8/14/25	SNDX	Syndax Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Podlesak Dennis	NY	D		S.dm	-875	15.19	-58	-23	192	D
8/18/25 16:35	8/14/25	RCKT	Rocket Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Schwartz Jonathan David	NJ	O	See Rema	S	-34	3.02	-11	-5	224	D
8/18/25 16:35	8/14/25	RCKT	Rocket Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Militello John	NJ	O	See Rema	S	-21	3.02	-7	-11	57	D
8/18/25 16:35	8/14/25	RCKT	Rocket Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Wilson Martin	NJ	O	GC	S	-37	3.02	-12	-8	137	D
8/18/25 16:34	8/15/25	ANIP	Ani Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Walsh Patrick D	MN	D		S	-801	89.05	-9	-11	70	D
8/18/25 16:33	8/15/25	EBS	Emergent Biosolutions Inc.	DE	Health	Drug	Pharmaceutical Preparations	Zoon Kathryn C	MD	D		S	-63	8.87	-7	-9	72	D
8/18/25 16:32	8/14/25	ANIP	Ani Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Shanmugam Muthusamy	MN	DO	HEAD OF	S.m	-8,825	88.25	-100	-14	630	I
8/18/25 16:31	8/14/25	SUPN	Supernus Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Sensenig Bethany	MD	D		S	-227	42.25	-5	-100	0	D
8/18/25 16:29	8/14/25	ZLAB	Zai Lab Ltd	E9	Health	Drug	Pharmaceutical Preparations	Chen Yajing	MA	O	CFO	M.d	0	0.00	1	8	17	D
8/18/25 16:29	8/15/25	ZLAB	Zai Lab Ltd	E9	Health	Drug	Pharmaceutical Preparations	Chen Yajing	MA	O	CFO	S.d	-51	35.42	-1	-8	17	D
8/18/25 16:29	8/15/25	ANIP	Ani Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Gassert Chad	MN	O	SVP - CO	S	-1,739	86.97	-20	-7	247	I
8/18/25 16:28	8/14/25	SUPN	Supernus Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Hudson Frederick M.	MD	D		S	-315	42.26	-7	-14	46	D
8/18/25 16:28	8/15/25	EOLS	Evolus, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Stewart Brady	CA	D		P	204	6.82	30	51	89	D
8/18/25 16:19	8/14/25	INSM	Insmed Inc	VA	Health	Drug	Pharmaceutical Preparations	Schaeffer Orlov S Nicole	NJ	O	Chief Pe	S	-1,273	127.34	-10	-11	80	D
8/18/25 12:00	8/14/25	CALC	Calcimedica, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Hebbar Sudarshan	CA	O	Chief Me	P.m	16	2.74	6	13	52	D
8/15/25 19:23	8/13/25	IRON	Disc Medicine, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Bitterman Kevin	MA	D		S.m	-1,966	61.11	-32	-3	1,064	I
8/15/25 19:11	8/14/25	BYSI	Beyondspring Inc.		Health	Drug	Pharmaceutical Preparations	Decheng Capital China Life Sciences Usd Fund Iii, L.P.	CA	T		S.m	-10	2.00	-5	0	4,483	I
8/15/25 18:13	8/15/25	CNTA	Centessa Pharmaceuticals Plc	X0	Health	Drug	Pharmaceutical Preparations	Hussain Iqbal J	X0	O	GC	M.d	35	5.84	6	6	111	D
8/15/25 18:13	8/15/25	CNTA	Centessa Pharmaceuticals Plc	X0	Health	Drug	Pharmaceutical Preparations	Hussain Iqbal J	X0	O	GC	S.d	-103	17.23	-6	-5	111	D
8/15/25 18:04	8/15/25	MDGL	Madrigal Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Bate Kenneth	PA	D		M.d	165	16.46	10		3	D
8/15/25 18:04	8/15/25	MDGL	Madrigal Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Bate Kenneth	PA	D		S.d	-3,652	365.20	-10	-79	3	D
8/15/25 17:59	8/13/25	ARWR	Arrowhead Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Hamilton James C	CA	O	Chief Me	S.m	-200	20.00	-10	-4	262	D
8/15/25 17:50	8/15/25	RNA	Avidity Biosciences, Inc.	DE	Health	Drug	Pharmaceutical Preparations	McCarthy Teresa	CA	O	CHRO	M.d	223	22.34	10	11	97	D
8/15/25 17:50	8/15/25	RNA	Avidity Biosciences, Inc.	DE	Health	Drug	Pharmaceutical Preparations	McCarthy Teresa	CA	O	CHRO	S.d	-466	46.56	-10	-9	97	D
8/15/25 17:08	8/13/25	COLL	Collegium Pharmaceutical, Inc	VA	Health	Drug	Pharmaceutical Preparations	Dreyer Scott	MA	O	EVP,Chie	M.d	104	21.34	5	5	104	D
8/15/25 17:08	8/13/25	COLL	Collegium Pharmaceutical, Inc	VA	Health	Drug	Pharmaceutical Preparations	Dreyer Scott	MA	O	EVP,Chie	S.d	-185	38.03	-5	-4	104	D
8/15/25 17:05	8/13/25	MGNX	Macrogenics Inc	DE	Health	Drug	Pharmaceutical Preparations	Koenig Scott	MD	D		M.d	0	0.00	53	7	830	D
8/15/25 17:00	8/13/25	CYRX	Cryoport, Inc.	NV	Health	Drug	Pharmaceutical Preparations	Shelton Jerrell	TN	DO	P,CEO	M.d	125	5.00	25	2	1,062	D
8/15/25 16:57	8/13/25	XERS	Xeris Biopharma Holdings, Inc.		Health	Drug	Pharmaceutical Preparations	Johnson John	IL	D		S	-786	7.32	-108	-11	833	D
8/15/25 16:40	8/13/25	ONC	Beone Medicines Ltd.		Health	Drug	Pharmaceutical Preparations	Wu Xiaobin	V8	O	P,COO	M.dm	14,437	160.78	90	8	1,245	D
8/15/25 16:40	8/13/25	ONC	Beone Medicines Ltd.		Health	Drug	Pharmaceutical Preparations	Wu Xiaobin	V8	O	P,COO	S.dm	-27,348	304.56	-90	-7	1,245	D
8/15/25 16:38	8/13/25	ONC	Beone Medicines Ltd.		Health	Drug	Pharmaceutical Preparations	Lee Chan Henry	V8	O	SVP,GC	S.d	-3,309	300.45	-11	-4	252	D
8/15/25 16:38	8/13/25	ONC	Beone Medicines Ltd.		Health	Drug	Pharmaceutical Preparations	Lee Chan Henry	V8	O	SVP,GC	M.d	1,464	177.90	8	3	252	D

D	Derivative transaction in filing (usually option exercise)
M	Multiple transactions in filing; earliest reported transaction date and weighted average transaction price
A	Amended filing
E	Error detected in filing

S - Sale	Sale of securities on an exchange or to another person
S - Sale+OE	Sale of securities on an exchange or to another person (after option exercise)
F - Tax	Payment of exercise price or tax liability using portion of securities received from the company
P - Purchase	Purchase of securities on an exchange or from another person

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