O'Neil Patrick R. - Insider Stock Trading

TC	Stat	Stk	Ins	Fil	+d	+w	+m	+q	+h	+y	avg
S	%ret	1	1	41	-0	2	1	12	36	85	23
S	%wins				56	39	47	40	39	11	39

Filing Date	T Date	Ticker	Issuer	Inc	Sector	Ind	Industry	Owner	oSt	Rel	Title	T	TVal	Price	L	Qty	oc	Own	H	r2y	r1y	r6m	r3m	r6w	r3w	r7d	r3d	f1d	f1w	f1m	f3m	f6m	f1y
9/4/24 21:11	2/2/24	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	EVP CLO,	S.a	-99	49.67	0	-2	-4	49	D
2/2/24 19:55	2/2/24	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	EVP CLO,	S	-97	49.67	0	-2	-4	49	D
1/29/24 17:34	1/25/24	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	EVP CLO,	S	-334	51.75	0	-6	-12	47	D
1/18/24 17:59	1/16/24	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	EVP CLO,	M.d	0	0.00	0	21	63	53	D
1/18/24 17:59	1/17/24	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	EVP CLO,	S.d	-390	50.42	0	-8	-13	53	D
12/28/23 19:18	12/26/23	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	EVP CLO,	M.d	986	47.34	0	21	107	40	D
12/28/23 19:18	12/26/23	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	EVP CLO,	S.d	-1,072	51.46	0	-21	-34	40	D
5/24/23 20:25	5/24/23	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	EVP CLO,	S	-64	41.70	0	-2	-4	40	D
2/7/23 17:37	2/6/23	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	EVP CLO,	S	-78	40.86	0	-2	-4	42	D
2/2/23 13:48	1/30/23	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	EVP CLO,	S.m	-356	39.56	0	-9	-18	40	D
1/19/23 20:21	1/17/23	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	EVP CLO,	M.d	0	0.00	0	22	82	49	D
1/19/23 20:21	1/18/23	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	EVP CLO,	S.d	-309	39.49	0	-8	-14	49	D
4/14/22 18:02	4/12/22	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	EVP CLO,	S	-272	40.06	0	-7	-16	35	D
1/20/22 20:18	1/18/22	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	EVP CLO,	M.d	0	0.00	0	21	108	41	D
1/27/21 17:35	1/25/21	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	EVP,GC	S	-338	63.50	0	-5	-17	27	D
1/20/21 19:00	1/15/21	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	EVP,GC	M.d	0	0.00	0	17	108	32	D
2/11/20 17:40	2/10/20	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,GC	S	-231	59.60	0	-4	-16	21	D
1/17/20 18:39	1/15/20	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	0	0.00	0	12	96	25	D
4/5/19 19:29	4/3/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP Lega	M.dm	2,690	57.81	0	47		17	D
4/5/19 19:29	4/3/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP Lega	S.dm	-4,160	83.99	0	-50	-75	17	D
3/20/19 18:15	3/18/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP Lega	M.d	1,773	61.57	0	29		20	D
3/20/19 18:15	3/18/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP Lega	S.d	-2,269	78.79	0	-29	-59	20	D
3/1/19 17:40	2/27/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP Lega	M.d	1,209	45.11	0	27		20	D
3/1/19 17:40	2/27/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP Lega	S.d	-1,823	68.01	0	-27	-58	20	D
2/14/19 18:01	2/12/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP Lega	M.d	11	39.87	0	0	1	20	D
2/14/19 18:01	2/12/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP Lega	S.d	-16	59.50	0	0	-1	20	D
2/5/19 18:05	2/1/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP Lega	M.dm	781	39.87	0	20	999%	20	D
2/5/19 18:05	2/1/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP Lega	S.dm	-1,161	59.25	0	-20	-50	20	D
1/17/19 19:24	1/15/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP Lega	M.d	0	0.00	0	8	66	20	D
1/3/19 19:50	1/3/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP Lega	M.d	164	37.23	0	4	43	15	D
1/3/19 19:50	1/3/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP Lega	S.d	-241	54.80	0	-4	-23	15	D
3/13/18 21:14	3/12/18	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP Lega	M.d	11	10.82	0	1	7	14	D
3/13/18 21:14	3/12/18	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP Lega	S.d	-55	55.00	0	-1	-6	14	D
1/31/18 16:16	1/29/18	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP Lega	M.d	4	10.82	0	0	3	14	D
1/31/18 16:16	1/29/18	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP Lega	S.d	-20	55.00	0	0	-2	14	D
1/29/18 16:08	1/25/18	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP Lega	M.d	7	10.82	0	1	5	14	D
1/29/18 16:08	1/25/18	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP Lega	S.d	-35	55.00	0	-1	-4	14	D
1/17/18 21:25	1/15/18	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	0	0.00	0	7	86	14	D
1/17/18 21:25	1/16/18	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-140	51.76	0	-3	-16	14	D
12/1/17 19:03	12/1/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	11	10.82	0	1	11	10	D
12/1/17 19:03	12/1/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-56	55.50	0	-1	-9	10	D
11/3/17 17:20	11/1/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	11	10.82	0	1	11	10	D
11/3/17 17:20	11/1/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-58	58.35	0	-1	-9	10	D
10/6/17 16:41	10/5/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	10	10.11	0	1	11	10	D
10/6/17 16:41	10/5/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-55	55.00	0	-1	-9	10	D
9/7/17 20:23	9/5/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.dm	7	7.25	0	1	11	10	D
9/7/17 20:23	9/5/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.dm	-55	55.00	0	-1	-9	10	D
6/2/17 18:15	6/1/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	1	10.82	0	0	1	10	D
6/2/17 18:15	6/1/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-3	48.00	0	0	-1	10	D
5/3/17 18:01	5/1/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-32	48.75	33	-1	-6	10	D	-19	17	82	7	24	21	7	0	0	-2
5/3/17 18:01	5/1/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	5	10.82	33	1	5	10	D	-19	17	82	7	24	21	7	0	0	-2
4/26/17 17:58	4/24/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	5	10.82	33	1	5	10	D	-28	11	71	13	18	23	13	12	1	1
4/26/17 17:58	4/24/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-23	45.00	33	-1	-5	10	D	-28	11	71	13	18	23	13	12	1	1
4/13/17 19:25	4/12/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S	-40	40.07	33	-1	-9	10	D	-39	-8	22	-20	-27	4	2	1	0	2	12
3/2/17 19:11	3/1/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	5	10.82	33	1	5	11	D	-26	38	63	8	5	9	5	11	2	-13	-27
3/2/17 19:11	3/1/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-74	49.29	33	-2	-12	11	D	-26	38	63	8	5	9	5	11	2	-13	-27
2/8/17 18:32	2/6/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-69	46.17	33	-2	-11	12	D	-24	36	25	65	-16	-5	6	1	2	4	1	3
2/8/17 18:32	2/6/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	5	10.68	33	1	4	12	D	-24	36	25	65	-16	-5	6	1	2	4	1	3
1/18/17 18:37	1/15/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	0	0.00	33	6	75	13	D	-32	6	68	61	8	-13	-1	-5	-1	-10	0	-10
1/18/17 18:37	1/17/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-104	46.29	33	-2	-14	13	D	-32	6	68	61	8	-13	-1	-5	-1	-10	0	-10
12/7/16 19:27	12/5/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	4	10.82	33	0	4	10	D	-10	-17	120	58	75	-1	3	15	1	1	4	0
12/7/16 19:27	12/5/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-16	45.00	33	0	-4	10	D	-10	-17	120	58	75	-1	3	15	1	1	4	0
11/14/16 18:53	11/14/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	11	10.82	33	1	12	10	D	-17	-31	30	20	18	54	58	35	1	-6	-3	-1
11/14/16 18:53	11/14/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-45	45.00	33	-1	-10	10	D	-17	-31	30	20	18	54	58	35	1	-6	-3	-1
4/7/16 18:18	4/6/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	11	10.82	33	1	12	9	D	23	-24	12	-24	32	26	21	13	-2	3	-14	-35	-12	-7
4/7/16 18:18	4/6/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-45	45.00	33	-1	-10	9	D	23	-24	12	-24	32	26	21	13	-2	3	-14	-35	-12	-7
3/24/16 19:13	3/23/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	11	10.82	33	1	12	9	D	-7	-42	-17	-31	20	4	-1	3	-8	-3	5	-48	-16	-9
3/24/16 19:13	3/23/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-45	45.40	33	-1	-10	9	D	-7	-42	-17	-31	20	4	-1	3	-8	-3	5	-48	-16	-9
1/19/16 20:12	1/15/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	0	0.00	33	5	106	9	D	-8	-36	-23	0	-24	-26	-25	-10	5	12	-4	6	-30	13
1/19/16 20:12	1/19/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-78	41.46	33	-2	-17	9	D	-8	-36	-23	0	-24	-26	-25	-10	5	12	-4	6	-30	13
1/4/16 21:25	1/4/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	8	7.79	33	1	19	6	D	55	0	10	51	2	7	8	2	-1	-8	-42	-31	-60	-22
1/4/16 21:25	1/4/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-61	61.10	33	-1	-14	6	D	55	0	10	51	2	7	8	2	-1	-8	-42	-31	-60	-22
12/2/15 18:49	12/1/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	7	7.25	33	1	19	6	D	60	21	-7	27	50	-3	0	-1	-4	-3
12/2/15 18:49	12/1/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-62	61.50	33	-1	-14	6	D	60	21	-7	27	50	-3	0	-1	-4	-3
11/4/15 19:00	11/3/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	7	7.25	33	1	19	6	D	55	12	-15	-6	8	26	13	4	2	22	10
11/4/15 19:00	11/3/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-52	51.95	33	-1	-14	6	D	55	12	-15	-6	8	26	13	4	2	22	10
3/20/15 18:55	3/19/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	690	22.62	33	31		6	D	339	61	87	40	26	12	11	7	-6	-16	-11	-14	-24
3/20/15 18:55	3/19/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-2,285	74.85	33	-31	-83	6	D	339	61	87	40	26	12	11	7	-6	-16	-11	-14	-24
3/9/15 19:27	3/5/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	56	9.63	33	6	999%	6	D	306	35	80	31	-1	10	3	3	-1	1	-12	-5	-26
3/9/15 19:27	3/5/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-416	71.67	33	-6	-48	6	D	306	35	80	31	-1	10	3	3	-1	1	-12	-5	-26
1/20/15 19:56	1/15/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	0	0.00	33	3	121	6	D	394	45	141	71	32	9	1	-3	-4	1	-10	-10	-24
1/20/15 19:56	1/16/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-88	67.96	33	-1	-17	6	D	394	45	141	71	32	9	1	-3	-4	1	-10	-10	-24
1/5/15 20:03	1/2/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	15	10.15	33	2	58	4	D	469	54	73	60	23	0	-2	-2	-4	7	-5	-11	-20
1/5/15 20:03	1/2/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-93	62.12	33	-2	-27	4	D	469	54	73	60	23	0	-2	-2	-4	7	-5	-11	-20
12/3/14 19:27	12/1/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	11	7.25	33	2	67	4	D	477	38	93	32	29	3	3	1	-2	8	15	34	20	13
12/3/14 19:27	12/1/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-77	51.21	33	-2	-29	4	D	477	38	93	32	29	3	3	1	-2	8	15	34	20	13
11/5/14 18:07	11/3/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	11	7.25	33	2	67	4	D	434	36	91	38	9	17	1	-1	3	16	19	38	36	19
11/5/14 18:07	11/3/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-69	46.17	33	-2	-29	4	D	434	36	91	38	9	17	1	-1	3	16	19	38	36	19
10/3/14 19:06	10/1/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	12	7.72	33	2	67	4	D	173	4	-3	8	13	-7	-4	-4	-2	-5	18	58	57	10
10/3/14 19:06	10/1/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-57	38.04	33	-2	-29	4	D	173	4	-3	8	13	-7	-4	-4	-2	-5	18	58	57	10
9/4/14 19:13	9/2/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	15	10.29	33	2	67	4	D	190	50	-28	47	28	12	17	1	-2	2	-2	35	81	31
9/4/14 19:13	9/2/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-61	40.44	33	-2	-29	4	D	190	50	-28	47	28	12	17	1	-2	2	-2	35	81	31
8/12/14 18:51	8/11/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.dm	15	10.29	33	2	67	4	D	177	23	-30	42	1	16	12	5	4	4	15	29	77	46
8/12/14 18:51	8/11/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.dm	-53	35.00	33	-2	-29	4	D	177	23	-30	42	1	16	12	5	4	4	15	29	77	46
7/2/14 16:09	7/1/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	15	10.29	33	2	67	4	D	201	25	-11	-18	51	8	-3	-2	0	-12	-12	10	74	61
7/2/14 16:09	7/1/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-53	35.33	33	-2	-29	4	D	201	25	-11	-18	51	8	-3	-2	0	-12	-12	10	74	61
6/20/14 16:15	6/19/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	7	10.18	33	1	26	3	D	220	54	-8	-26	52	19	2	0	-1	-1	-23	15	60	74
6/20/14 16:15	6/19/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-25	35.35	33	-1	-17	3	D	220	54	-8	-26	52	19	2	0	-1	-1	-23	15	60	74
6/18/14 19:06	6/16/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	6	8.00	33	1	31	3	D	235	50	-8	-30	39	11	12	6	3	7	-18	17	68	81
6/18/14 19:06	6/16/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-28	35.14	33	-1	-19	3	D	235	50	-8	-30	39	11	12	6	3	7	-18	17	68	81
4/3/14 19:32	4/1/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	12	8.00	33	2	81	3	D	364	160	12	6	-17	-8	-1	6	-5	0	-32	-10	-4	52
4/3/14 19:32	4/1/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-67	44.40	33	-2	-31	3	D	364	160	12	6	-17	-8	-1	6	-5	0	-32	-10	-4	52
3/5/14 18:55	3/3/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	16	10.93	33	2	81	3	D	508	234	115	43	15	10	-6	-2	-7	-12	-25	-51	-27	26
3/5/14 18:55	3/3/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-75	50.00	33	-2	-31	3	D	508	234	115	43	15	10	-6	-2	-7	-12	-25	-51	-27	26
2/5/14 19:30	2/3/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	17	11.27	33	2	81	3	D	495	245	74	51	20	2	3	0	-1	7	11	-44	-29	26
2/5/14 19:30	2/3/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-76	50.45	33	-2	-31	3	D	495	245	74	51	20	2	3	0	-1	7	11	-44	-29	26
1/17/14 19:36	1/15/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	0	0.00	33	2	82	3	D	528	240	57	40	23	16	22	1	2	3	9	-28	-39	47
1/17/14 19:36	1/16/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-27	47.08	33	-1	-15	3	D	528	240	57	40	23	16	22	1	2	3	9	-28	-39	47
9/6/13 19:03	9/4/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	28	11.29	33	3		2	D	294	109	61	31	-3	10	11	10	14	11	29	38	82	36
9/6/13 19:03	9/4/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-68	27.09	33	-3	-55	2	D	294	109	61	31	-3	10	11	10	14	11	29	38	82	36
7/5/13 18:01	7/5/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S	-8	29.25	33	0	-12	2	D	211	138	163	70	40	21	0	6	0	10	-3	25	35	19
4/23/13 21:04	4/19/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.dm	585	13.83	26	42		1	D	150	202	112	52	23	30	14	14	1	2	-6	40	48	68
4/23/13 21:04	4/19/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.dm	-910	21.50	26	-42	-97	1	D	150	202	112	52	23	30	14	14	1	2	-6	40	48	68
4/15/13 19:09	4/12/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	78	14.24	27	5		1	D	112	147	57	45	25	14	18	9	4	14	5	80	78	81
4/15/13 19:09	4/12/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-107	19.61	27	-5	-80	1	D	112	147	57	45	25	14	18	9	4	14	5	80	78	81
3/22/13 19:56	3/21/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	128	14.18	27	9		1	D	108	109	24	79	25	17	0	2	1	1	28	22	108	151
3/22/13 19:56	3/21/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-173	19.26	27	-9	-87	1	D	108	109	24	79	25	17	0	2	1	1	28	22	108	151
3/4/13 20:05	3/4/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	132	11.25	14	12		1	D	68	78	11	69	8	8	5	9	3	7	1	33	61	224
3/4/13 20:05	3/4/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-185	15.82	14	-12	-90	1	D	68	78	11	69	8	8	5	9	3	7	1	33	61	224
2/20/13 19:03	2/15/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.dm	20	10.29	24	2		1	D	72	79	12	85	41	12	4	5	-3	-4	22	39	71	244
2/20/13 19:03	2/15/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.dm	-29	14.80	24	-2	-60	1	D	72	79	12	85	41	12	4	5	-3	-4	22	39	71	244
2/14/13 20:35	2/13/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	45	7.36	25	6		1	D	63	71	12	66	31	5	-2	0	0	-2	23	44	84	264
2/14/13 20:35	2/13/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-88	14.17	25	-6	-82	1	D	63	71	12	66	31	5	-2	0	0	-2	23	44	84	264
1/31/13 19:57	1/29/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.dm	-34	14.63	29	-2	-61	1	D	54	78	13	65	46	23	2	8	1	1	5	48	97	241
1/31/13 19:57	1/30/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	21	10.29	29	2		1	D	54	78	13	65	46	23	2	8	1	1	5	48	97	241
1/17/13 20:35	1/15/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	M.d	0	0.00	19	1	44	2	D	41	85	4	11	56	39	32	6	1	-4	2	37	115	239
1/17/13 20:35	1/17/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S.d	-3	14.16	19	0	-12	2	D	41	85	4	11	56	39	32	6	1	-4	2	37	115	239
1/4/13 20:00	1/4/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	SVP,Lega	S	-14	10.76	15	-1	-47	1	D	4	45	-19	-24	17	10	2	4	-2	22	34	62	182	268

D	Derivative transaction in filing (usually option exercise)
M	Multiple transactions in filing; earliest reported transaction date and weighted average transaction price
A	Amended filing
E	Error detected in filing

S - Sale	Sale of securities on an exchange or to another person
S - Sale+OE	Sale of securities on an exchange or to another person (after option exercise)
F - Tax	Payment of exercise price or tax liability using portion of securities received from the company
P - Purchase	Purchase of securities on an exchange or from another person

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