Crooke Stanley T - Insider Stock Trading

TC	Stat	Stk	Ins	Fil	+d	+w	+m	+q	+h	+y	avg
P	%ret	1	1	1	2	1	18	14	71	108	36
P	%wins				100	100	100	100	100	100	100
S	%ret	1	1	78	-0	-0	-4	-0	7	18	3
S	%wins				64	53	71	59	52	48	58

Filing Date	T Date	Ticker	Issuer	Inc	Sector	Ind	Industry	Owner	oSt	Rel	Title	T	TVal	Price	L	Qty	oc	Own	H	r2y	r1y	r6m	r3m	r6w	r3w	r7d	r3d	f1d	f1w	f1m	f3m	f6m	f1y
1/28/21 19:22	1/26/21	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	Exec CB	S	-1,806	63.74	0	-28	-5	500	D
1/25/21 20:24	1/21/21	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	Exec CB	S.m	-4,609	61.45	0	-75	-12	528	I
1/20/21 19:12	1/15/21	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	Exec CB	M.d	0	0.00	0	52	9	603	M
12/17/20 19:42	12/15/20	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	Exec CB	S.m	-2,012	49.80	0	-40	-6	603	I
12/9/20 20:14	12/7/20	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	Exec CB	S	-568	51.67	0	-11	-2	643	I
11/30/20 18:48	11/25/20	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	Exec CB	M.d	518	39.87	0	13	2	654	D
11/30/20 18:48	11/25/20	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	Exec CB	S.d	-650	50.05	0	-13	-2	654	D
11/25/20 19:04	11/23/20	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	Exec CB	M.dm	586	39.87	0	15	2	654	M
11/25/20 19:04	11/23/20	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	Exec CB	S.dm	-738	50.23	0	-15	-2	654	M
9/23/20 18:44	9/21/20	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	Exec CB	S.m	-2,621	50.40	0	-52	-7	654	I
6/26/20 19:47	6/24/20	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	Exec CB	S.m	-890	59.67	0	-15	-2	702	D
6/19/20 19:03	6/17/20	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	Exec CB	S.m	-1,568	58.08	0	-27	-4	721	M
3/27/20 19:05	3/25/20	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	Exec CB	S	-752	47.00	0	-16	-2	748	M
3/27/20 19:01	3/17/20	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	Exec CB	S.a	-895	44.75	0	-20	-3	772	D
3/23/20 18:17	3/19/20	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	Exec CB	S	-723	45.16	0	-16	-2	764	M
3/19/20 13:55	3/17/20	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	Exec CB	S	-912	44.75	0	-20	-3	772	D
1/17/20 18:28	1/15/20	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	Exec CB	M.d	0	0.00	0	43	6	800	M
8/22/19 18:41	8/20/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.dm	877	39.87	0	22	3	801	M
8/22/19 18:41	8/20/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.dm	-1,574	71.52	0	-22	-3	801	M
7/22/19 17:34	7/18/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	399	39.87	0	10	1	795	D
7/22/19 17:34	7/18/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-703	70.25	0	-10	-1	795	D
4/17/19 19:30	4/15/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.dm	818	25.56	0	32	4	801	M
4/17/19 19:30	4/15/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.dm	-2,715	84.84	0	-32	-4	801	M
2/27/19 19:31	2/25/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.dm	3,070	39.87	0	77	11	795	D
2/27/19 19:31	2/25/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.dm	-4,679	60.77	0	-77	-9	795	D
2/14/19 17:57	2/13/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	1,823	38.88	0	47	6	801	M
2/14/19 17:57	2/13/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-2,818	60.09	0	-47	-6	801	M
1/17/19 19:27	1/15/19	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	0	0.00	0	33	4	801	M
4/19/18 17:22	4/17/18	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	190	13.58	0	14	2	781	M
4/19/18 17:22	4/17/18	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-620	44.40	0	-14	-2	781	M
1/31/18 16:15	1/29/18	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.ad	158	14.34	0	11	1	781	M
1/31/18 16:15	1/29/18	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.ad	-595	54.12	0	-11	-1	781	M
1/17/18 21:22	1/15/18	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	0	0.00	0	31	4	781	M
1/17/18 21:22	1/15/18	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-857	51.76	0	-17	-2	781	M
1/10/18 18:43	1/8/18	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	158	14.34	0	11	1	766	M
1/10/18 18:43	1/8/18	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-572	52.01	0	-11	-1	766	M
1/5/18 16:41	1/3/18	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	312	14.19	0	22	3	766	M
1/5/18 16:41	1/3/18	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-1,100	50.01	0	-22	-3	766	M
10/17/17 17:36	10/13/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	231	14.01	0	17	2	766	M
10/17/17 17:36	10/13/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-981	59.46	0	-17	-2	766	M
10/4/17 19:15	10/2/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.dm	385	14.01	0	28	4	766	M
10/4/17 19:15	10/2/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.dm	-1,454	52.89	0	-28	-3	766	M
7/24/17 17:54	7/20/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	154	14.01	0	11	1	766	M
7/24/17 17:54	7/20/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-609	55.35	0	-11	-1	766	M
7/18/17 19:01	7/17/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	231	14.01	0	17	2	766	M
7/18/17 19:01	7/17/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-865	52.45	0	-17	-2	766	M
7/3/17 17:34	7/3/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	131	7.94	0	17	2	766	M
7/3/17 17:34	7/3/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-860	52.10	0	-17	-2	766	M
4/27/17 18:03	4/25/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	120	7.25	33	17	2	766	M	-24	12	70	9	13	24	11	6	1	1
4/27/17 18:03	4/25/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-789	47.81	33	-17	-2	766	M	-24	12	70	9	13	24	11	6	1	1
4/21/17 17:42	4/19/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	40	7.25	33	6	1	766	M	-35	-2	50	-8	-6	6	11	2	3	8
4/21/17 17:42	4/19/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-238	43.25	33	-6	-1	766	M	-35	-2	50	-8	-6	6	11	2	3	8
4/13/17 19:24	4/12/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.dm	164	7.46	33	22	3	766	M	-39	-8	22	-20	-27	4	2	1	0	2	12
4/13/17 19:24	4/12/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.dm	-895	40.69	33	-22	-3	766	M	-39	-8	22	-20	-27	4	2	1	0	2	12
3/6/17 19:23	3/2/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	91	7.53	33	12	2	766	M	-22	42	84	25	16	20	20	10	-7	-15	-21
3/6/17 19:23	3/2/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-618	51.05	33	-12	-2	766	M	-22	42	84	25	16	20	20	10	-7	-15	-21
1/18/17 18:36	1/15/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	0	0.00	33	30	4	766	M	-32	6	68	61	8	-13	-1	-5	-1	-10	0	-10
1/18/17 18:36	1/17/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-739	46.29	33	-16	-2	766	M	-32	6	68	61	8	-13	-1	-5	-1	-10	0	-10
1/12/17 18:18	1/10/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	99	7.53	33	13	2	753	M	-33	1	98	51	6	-6	2	2	-3	-6	-8	-21
1/12/17 18:18	1/10/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-650	49.25	33	-13	-2	753	M	-33	1	98	51	6	-6	2	2	-3	-6	-8	-21
1/4/17 18:35	1/3/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.dm	141	7.53	33	19	3	753	M	-23	-23	93	31	5	5	-9	-8	-5	2	-10	-22
1/4/17 18:35	1/3/17	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.dm	-914	48.89	33	-19	-2	753	M	-23	-23	93	31	5	5	-9	-8	-5	2	-10	-22
11/14/16 18:51	11/9/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.dm	298	9.02	33	33	5	753	M	-17	-31	30	20	18	54	58	35	1	-6	-3	-1
11/14/16 18:51	11/9/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.dm	-1,245	37.72	33	-33	-4	753	M	-17	-31	30	20	18	54	58	35	1	-6	-3	-1
10/7/16 17:49	10/5/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	113	10.29	33	11	1	753	M	-7	-19	-15	35	13	8	-7	-5	0	-12	-21	40	13
10/7/16 17:49	10/5/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-403	36.61	33	-11	-1	753	M	-7	-19	-15	35	13	8	-7	-5	0	-12	-21	40	13
9/29/16 17:05	9/27/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	226	10.29	33	22	3	753	M	-10	-5	-11	56	5	17	14	3	3	2	-27	44	13
9/29/16 17:05	9/27/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-793	36.02	33	-22	-3	753	M	-10	-5	-11	56	5	17	14	3	3	2	-27	44	13
9/23/16 18:31	9/21/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	226	10.29	33	22	3	753	M	-13	-26	-16	48	-2	17	19	11	-1	1	-20	49	11
9/23/16 18:31	9/21/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-781	35.50	33	-22	-3	753	M	-13	-26	-16	48	-2	17	19	11	-1	1	-20	49	11
4/7/16 18:18	4/6/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	113	10.29	33	11	1	753	M	23	-24	12	-24	32	26	21	13	-2	3	-14	-35	-12	-7
4/7/16 18:18	4/6/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-507	46.13	33	-11	-1	753	M	23	-24	12	-24	32	26	21	13	-2	3	-14	-35	-12	-7
4/1/16 18:18	3/31/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	113	10.24	33	11	1	753	M	-6	-36	6	-33	9	9	0	6	3	1	0	-44	-12	-2
4/1/16 18:18	3/31/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-448	40.74	33	-11	-1	753	M	-6	-36	6	-33	9	9	0	6	3	1	0	-44	-12	-2
1/19/16 20:27	1/15/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	0	0.00	33	25	3	753	M	-8	-36	-23	0	-24	-26	-25	-10	5	12	-4	6	-30	13
1/19/16 20:27	1/19/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-556	41.46	33	-13	-2	753	M	-8	-36	-23	0	-24	-26	-25	-10	5	12	-4	6	-30	13
1/7/16 18:52	1/5/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	56	10.19	33	6	1	741	M	52	-10	10	46	-5	4	-2	-5	3	-20	-34	-24	-52	-14
1/7/16 18:52	1/5/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-342	62.10	33	-6	-1	741	M	52	-10	10	46	-5	4	-2	-5	3	-20	-34	-24	-52	-14
1/4/16 21:22	1/4/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	112	10.19	33	11	2	741	M	55	0	10	51	2	7	8	2	-1	-8	-42	-31	-60	-22
1/4/16 21:22	1/4/16	IONS	Ionis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-672	61.05	33	-11	-1	741	M	55	0	10	51	2	7	8	2	-1	-8	-42	-31	-60	-22
10/23/15 19:35	10/21/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.dm	469	10.67	33	44	6	741	M	26	6	-35	-19	-21	-1	5	-3	2	9	37
10/23/15 19:35	10/21/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.dm	-1,929	43.85	33	-44	-6	741	M	26	6	-35	-19	-21	-1	5	-3	2	9	37
7/8/15 17:54	7/6/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	67	10.88	33	6	1	741	M	85	67	-19	-10	-17	-11	-11	-3	0	6	3	-21
7/8/15 17:54	7/6/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-352	57.01	33	-6	-1	741	M	85	67	-19	-10	-17	-11	-11	-3	0	6	3	-21
7/2/15 18:02	7/1/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	67	10.88	33	6	1	741	M	101	61	-7	-10	-15	-16	-12	-3	-1	-5	-2	-27
7/2/15 18:02	7/1/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-355	57.56	33	-6	-1	741	M	101	61	-7	-10	-15	-16	-12	-3	-1	-5	-2	-27
4/8/15 17:11	4/7/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	248	11.08	33	22	3	741	M	255	63	56	-10	-9	-15	1	-3	3	5	-3	-11	-33
4/8/15 17:11	4/7/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-1,411	63.07	33	-22	-3	741	M	255	63	56	-10	-9	-15	1	-3	3	5	-3	-11	-33
4/6/15 11:50	4/1/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	240	11.08	33	22	3	741	M	278	46	63	0	-8	-13	-10	-5	0	7	-3	-9	-34
4/6/15 11:50	4/1/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-1,339	61.93	33	-22	-3	741	M	278	46	63	0	-8	-13	-10	-5	0	7	-3	-9	-34
1/29/15 19:03	1/27/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	122	11.08	33	11	2	741	M	408	37	117	50	20	0	-1	-4	-2	-15	-2	-15	-25
1/29/15 19:03	1/27/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-802	72.93	33	-11	-1	741	M	408	37	117	50	20	0	-1	-4	-2	-15	-2	-15	-25
1/20/15 20:00	1/15/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	0	0.00	33	17	2	741	M	394	45	141	71	32	9	1	-3	-4	1	-10	-10	-24
1/20/15 20:00	1/16/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-615	67.96	33	-9	-1	741	M	394	45	141	71	32	9	1	-3	-4	1	-10	-10	-24
1/13/15 18:51	1/9/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	122	11.08	33	11	2	733	M	455	54	141	101	42	13	19	7	1	1	-14	-9	-21
1/13/15 18:51	1/9/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-809	73.57	33	-11	-1	733	M	455	54	141	101	42	13	19	7	1	1	-14	-9	-21
1/8/15 19:15	1/6/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.dm	244	11.08	33	22	3	733	M	545	75	122	85	31	25	8	11	1	1	-19	-11	-27
1/8/15 19:15	1/6/15	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.dm	-1,475	67.04	33	-22	-3	733	M	545	75	122	85	31	25	8	11	1	1	-19	-11	-27
10/24/14 16:57	10/23/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	171	11.70	33	15	2	733	M	353	25	29	41	3	8	15	3	2	2	14	66	40	1
10/24/14 16:57	10/23/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-616	42.22	33	-15	-2	733	M	353	25	29	41	3	8	15	3	2	2	14	66	40	1
10/3/14 19:07	10/1/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.dm	508	14.10	33	36	5	733	M	173	4	-3	8	13	-7	-4	-4	-2	-5	18	58	57	10
10/3/14 19:07	10/1/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.dm	-1,387	38.52	33	-36	-5	733	M	173	4	-3	8	13	-7	-4	-4	-2	-5	18	58	57	10
8/15/14 18:39	8/13/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.d	242	14.17	33	17	2	733	M	188	39	-30	43	3	21	13	5	0	-5	7	41	76	38
8/15/14 18:39	8/13/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.d	-606	35.45	33	-17	-2	733	M	188	39	-30	43	3	21	13	5	0	-5	7	41	76	38
8/1/14 19:44	8/1/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.d	228	14.27	33	16	2	733	M	138	7	-38	21	-11	1	4	3	3	8	33	47	123	79
8/1/14 19:44	8/1/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.d	-488	30.53	33	-16	-2	733	M	138	7	-38	21	-11	1	4	3	3	8	33	47	123	79
7/2/14 16:08	7/1/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	247	14.14	33	18	2	733	M	201	25	-11	-18	51	8	-3	-2	0	-12	-12	10	74	61
7/2/14 16:08	7/1/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-623	35.57	33	-18	-2	733	M	201	25	-11	-18	51	8	-3	-2	0	-12	-12	10	74	61
6/20/14 16:14	6/19/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.d	159	14.47	33	11	2	733	D	220	54	-8	-26	52	19	2	0	-1	-1	-23	15	60	74
6/20/14 16:14	6/19/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.d	-386	35.10	33	-11	-1	733	D	220	54	-8	-26	52	19	2	0	-1	-1	-23	15	60	74
6/12/14 18:43	6/10/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.d	159	14.47	33	11	2	733	M	229	39	-14	-33	24	42	15	8	4	5	-4	23	78	109
6/12/14 18:43	6/10/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.d	-368	33.46	33	-11	-1	733	M	229	39	-14	-33	24	42	15	8	4	5	-4	23	78	109
4/4/14 19:24	4/2/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.d	127	14.47	33	9	1	733	M	351	136	7	-1	-33	-13	-9	-8	-1	-4	-31	-6	2	60
4/4/14 19:24	4/2/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.d	-384	43.65	33	-9	-1	733	M	351	136	7	-1	-33	-13	-9	-8	-1	-4	-31	-6	2	60
1/17/14 19:37	1/15/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.d	0	0.00	33	9	1	733	M	528	240	57	40	23	16	22	1	2	3	9	-28	-39	47
1/17/14 19:37	1/16/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.d	-166	47.08	33	-4	0	733	M	528	240	57	40	23	16	22	1	2	3	9	-28	-39	47
1/10/14 19:24	1/8/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.d	181	14.47	33	13	2	727	M	535	285	41	43	21	18	16	20	-1	0	4	-25	-36	53
1/10/14 19:24	1/8/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.d	-501	40.05	33	-13	-2	727	M	535	285	41	43	21	18	16	20	-1	0	4	-25	-36	53
1/3/14 19:46	1/2/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.d	456	14.47	33	32	5	727	M	459	268	40	7	25	9	-4	-1	-1	18	25	1	-9	57
1/3/14 19:46	1/2/14	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.d	-1,239	39.35	33	-32	-4	727	M	459	268	40	7	25	9	-4	-1	-1	18	25	1	-9	57
9/23/13 19:39	9/19/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.dm	653	11.12	33	59	9	727	D	428	147	114	64	28	40	15	13	-2	0	-18	1	12	6
9/23/13 19:39	9/19/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.dm	-2,067	35.19	33	-59	-7	727	D	428	147	114	64	28	40	15	13	-2	0	-18	1	12	6
9/11/13 19:27	9/9/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	COO,P	M.d	296	11.12	33	27	4	727	M	327	107	76	34	11	22	22	11	-1	2	3	22	56	27
9/11/13 19:27	9/9/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	COO,P	S.dm	-2,383	31.10	33	-77	-10	727	M	327	107	76	34	11	22	22	11	-1	2	3	22	56	27
7/25/13 20:18	7/23/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	COO,P	M.d	128	11.12	33	12	2	777	D	223	120	112	28	25	0	-15	-8	-1	-2	-13	17	73	5
7/25/13 20:18	7/23/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	COO,P	S.d	-345	30.00	33	-12	-1	777	D	223	120	112	28	25	0	-15	-8	-1	-2	-13	17	73	5
7/22/13 19:51	7/18/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.dm	863	13.88	33	62	9	777	D	254	126	119	47	36	16	-2	-1	-6	-6	-18	8	52	-7
7/22/13 19:51	7/18/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.dm	-1,897	30.50	33	-62	-7	777	D	254	126	119	47	36	16	-2	-1	-6	-6	-18	8	52	-7
7/17/13 19:41	7/15/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.dm	578	11.72	33	49	7	777	M	240	138	129	64	48	18	4	-4	-3	-7	-16	6	56	-8
7/17/13 19:41	7/15/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.dm	-1,633	33.12	33	-49	-6	777	M	240	138	129	64	48	18	4	-4	-3	-7	-16	6	56	-8
7/12/13 19:44	7/10/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.dm	1,282	14.24	33	90	13	777	D	251	134	173	70	50	58	15	9	-1	-10	-17	-5	38	-9
7/12/13 19:44	7/10/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.dm	-2,858	31.75	33	-90	-10	777	D	251	134	173	70	50	58	15	9	-1	-10	-17	-5	38	-9
7/9/13 19:38	7/5/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.dm	910	15.38	33	59	8	777	D	233	133	176	73	43	32	7	6	6	12	-7	20	29	5
7/9/13 19:38	7/5/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.dm	-2,914	26.69	33	-109	-12	777	D	233	133	176	73	43	32	7	6	6	12	-7	20	29	5
7/1/13 19:33	6/27/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.dm	303	7.44	33	41	6	777	M	195	132	161	58	30	17	19	1	0	6	0	37	43	22
7/1/13 19:33	6/27/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.dm	-1,401	27.65	33	-51	-6	777	M	195	132	161	58	30	17	19	1	0	6	0	37	43	22
6/26/13 19:46	6/24/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	S.dm	-2,405	26.73	33	-90	-10	787	M	203	145	160	59	32	27	16	28	-3	2	5	36	51	30
6/26/13 19:46	6/25/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO	M.dm	341	6.81	33	50	7	787	M	203	145	160	59	32	27	16	28	-3	2	5	36	51	30
4/26/13 19:01	4/24/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO,P	S	-221	22.12	28	-10	-1	827	I	156	200	140	65	26	29	18	3	1	0	-7	30	51	46
4/23/13 20:46	4/19/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO,P	M.dm	363	7.26	26	50	6	837	M	150	202	112	52	23	30	14	14	1	2	-6	40	48	68
4/23/13 20:46	4/19/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO,P	S.dm	-1,893	21.03	26	-90	-10	837	M	150	202	112	52	23	30	14	14	1	2	-6	40	48	68
1/17/13 20:39	1/15/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO,P	M.d	0	0.00	19	3	0	877	M	41	85	4	11	56	39	32	6	1	-4	2	37	115	239
1/17/13 20:39	1/16/13	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO,P	S.d	-20	14.00	19	-1	0	877	M	41	85	4	11	56	39	32	6	1	-4	2	37	115	239
10/11/12 19:52	10/10/12	RGLS	Regulus Therapeutics Inc.	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DT		P.d	3,000	4.00	0	750	12	7,050	I									2	1	18	14	71	108
9/21/12 19:20	9/19/12	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO,P	M.dm	549	6.14	15	89	11	875	D	80	126	80	42	20	13	6	7	0	0	-33	-27	16	151
9/21/12 19:20	9/19/12	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO,P	S.dm	-1,309	14.63	15	-89	-9	875	D	80	126	80	42	20	13	6	7	0	0	-33	-27	16	151
9/17/12 18:36	9/13/12	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO,P	M.d	142	5.25	14	27	3	873	D	77	104	71	35	21	7	-1	0	1	-1	-9	-30	23	119
9/17/12 18:36	9/13/12	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO,P	S.d	-394	14.55	14	-27	-3	873	D	77	104	71	35	21	7	-1	0	1	-1	-9	-30	23	119
9/6/12 21:38	9/4/12	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO,P	M.dm	397	5.29	16	75	9	875	M	86	109	78	45	19	10	9	9	-3	-4	-18	-42	16	112
9/6/12 21:38	9/4/12	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,CEO,P	S.dm	-1,096	14.62	16	-75	-8	875	M	86	109	78	45	19	10	9	9	-3	-4	-18	-42	16	112
12/22/11 17:21	12/21/11	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.d	103	5.80	4	18	2	875	M	-32	-33	-21	3	-1	-3	0	5	-1	2	12	22	69	44
12/22/11 17:21	12/21/11	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.d	-123	6.92	4	-18	-2	875	M	-32	-33	-21	3	-1	-3	0	5	-1	2	12	22	69	44
12/20/11 21:09	12/16/11	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.dm	367	5.80	4	63	8	875	M	-32	-34	-23	-1	-18	-3	-2	0	1	0	13	24	60	48
12/20/11 21:09	12/16/11	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.dm	-432	6.82	4	-63	-7	875	M	-32	-34	-23	-1	-18	-3	-2	0	1	0	13	24	60	48
12/29/10 19:22	12/27/10	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.dm	308	9.63	5	32	4	875	M	-22	-7	7	24	4	7	1	-2	-2	0	-8	-15	-10	-32
12/29/10 19:22	12/27/10	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.dm	-332	10.38	5	-32	-4	875	M	-22	-7	7	24	4	7	1	-2	-2	0	-8	-15	-10	-32
12/27/10 16:09	12/22/10	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.dm	193	9.63	5	20	2	875	D	-22	-6	6	21	7	10	7	2	-2	-4	-12	-17	-15	-33
12/27/10 16:09	12/22/10	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.dm	-210	10.52	5	-20	-2	875	D	-22	-6	6	21	7	10	7	2	-2	-4	-12	-17	-15	-33
12/30/09 19:49	12/30/09	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.d	45	6.81	15	7	1	875	I	-32	-15	-33	-25	-17	6	12	0	-1	2	-1	-3	-15	-8
12/30/09 19:49	12/30/09	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.d	-72	11.07	15	-7	-1	875	I	-32	-15	-33	-25	-17	6	12	0	-1	2	-1	-3	-15	-8
12/23/09 17:36	12/22/09	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.d	136	6.81	14	20	2	875	D	-36	-22	-32	-31	-23	-2	5	5	0	1	-2	-5	-17	-6
12/23/09 17:36	12/22/09	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.d	-203	10.13	14	-20	-2	875	D	-36	-22	-32	-31	-23	-2	5	5	0	1	-2	-5	-17	-6
12/17/09 19:14	12/15/09	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.dm	341	6.81	16	50	6	875	D	-35	-16	-34	-33	-19	-9	-3	2	0	12	14	0	-6	3
12/17/09 19:14	12/15/09	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.dm	-503	10.07	16	-50	-5	875	D	-35	-16	-34	-33	-19	-9	-3	2	0	12	14	0	-6	3
12/14/09 19:59	12/10/09	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.dm	477	6.81	24	70	9	875	D	-41	-12	-30	-36	-21	-11	-6	-5	0	0	15	-2	-3	-3
12/14/09 19:59	12/10/09	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.dm	-701	10.02	24	-70	-7	875	D	-41	-12	-30	-36	-21	-11	-6	-5	0	0	15	-2	-3	-3
12/10/09 19:21	12/8/09	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.dm	341	6.81	23	50	6	875	D	-41	-14	-34	-35	-17	-9	-5	-3	-2	0	14	-5	-8	-6
12/10/09 19:21	12/8/09	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.dm	-521	10.42	23	-50	-5	875	D	-41	-14	-34	-35	-17	-9	-5	-3	-2	0	14	-5	-8	-6
12/8/09 19:40	12/4/09	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.dm	409	6.81	22	60	7	875	D	-39	-8	-32	-32	-20	-21	-6	-1	-3	-5	8	-5	-16	-9
12/8/09 19:40	12/4/09	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.dm	-632	10.54	22	-60	-6	875	D	-39	-8	-32	-32	-20	-21	-6	-1	-3	-5	8	-5	-16	-9
1/2/09 17:18	12/30/08	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.d	97	12.94	10	8	1	875	B									0	-3	-2	6	10	-24
1/2/09 17:18	12/30/08	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.d	-100	13.37	10	-8	-1	875	B									0	-3	-2	6	10	-24
12/29/08 19:20	12/23/08	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.dm	224	12.94	9	17	2	875	M	16	-17	-3	-24	-12	17	10	0	5	10	11	13	27	-14
12/29/08 19:20	12/23/08	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.dm	-232	13.40	9	-17	-2	875	M	16	-17	-3	-24	-12	17	10	0	5	10	11	13	27	-14
12/22/08 18:16	12/19/08	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.d	168	12.94	11	13	2	875	M	19	-13	0	-16	-6	35	18	15	1	-2	-1	4	12	-23
12/22/08 18:16	12/19/08	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.d	-181	13.93	11	-13	-1	875	M	19	-13	0	-16	-6	35	18	15	1	-2	-1	4	12	-23
12/19/08 16:16	12/17/08	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.d	63	5.15	11	12	1	875	M	10	-16	-8	-22	-8	16	13	21	-5	-5	-3	3	8	-30
12/19/08 16:16	12/17/08	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.d	-156	12.80	11	-12	-1	875	M	10	-16	-8	-22	-8	16	13	21	-5	-5	-3	3	8	-30
12/28/07 19:57	12/26/07	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.dm	641	12.31	27	52	6	875	M	206	40	64	5	0	-7	3	-1	-3	-8	-4	-13	-15	-18
12/28/07 19:57	12/26/07	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.dm	-819	16.38	27	-50	-5	875	M	206	40	64	5	0	-7	3	-1	-3	-8	-4	-13	-15	-18
12/13/07 20:04	12/11/07	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.d	246	12.31	33	20	2	873	D	222	36	89	27	-4	3	-4	1	-3	-7	-2	-19	-13	-34
12/13/07 20:04	12/11/07	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.d	-347	17.37	33	-20	-2	873	D	222	36	89	27	-4	3	-4	1	-3	-7	-2	-19	-13	-34
11/30/07 18:01	11/28/07	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.dm	308	5.15	33	60	7	873	D	236	75	75	44	0	11	6	3	0	-2	-11	-18	-21	-35
11/30/07 18:01	11/28/07	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.dm	-1,078	18.02	33	-60	-6	873	D	236	75	75	44	0	11	6	3	0	-2	-11	-18	-21	-35
11/13/06 20:24	11/9/06	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.m	-574	11.48	9	-50	-5	873	D	132	107	30	68	44	21	26	14	-11	-18	-4	-26	-27	32
12/13/04 19:50	12/10/04	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.dm	17	4.00	5	4	0	923	M		19	10	15	33	45	26	7	-2	-7	-20	-33	-37	-15
12/13/04 19:50	12/10/04	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.dm	-26	6.17	5	-4	0	923	M		19	10	15	33	45	26	7	-2	-7	-20	-33	-37	-15
12/8/04 20:32	12/2/04	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.adm	85	4.00	4	21	2	923	D		4	-8	-1	19	32	29	-3	4	4	-12	-31	-40	-11
12/8/04 20:32	12/2/04	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.adm	-123	5.77	4	-21	-2	923	D		4	-8	-1	19	32	29	-3	4	4	-12	-31	-40	-11
12/8/04 20:31	12/7/04	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.dm	36	4.00	4	9	1	923	D		4	-8	-1	19	32	29	-3	4	4	-12	-31	-40	-11
12/8/04 20:31	12/7/04	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.dm	-53	5.88	4	-9	-1	923	D		4	-8	-1	19	32	29	-3	4	4	-12	-31	-40	-11
12/6/04 19:43	12/2/04	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.dm	93	4.00	4	23	3	923	D		6	-6	-2	24	33	34	26	-2	4	-9	-29	-37	-11
12/6/04 19:43	12/2/04	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.dm	-134	5.76	4	-23	-2	923	D		6	-6	-2	24	33	34	26	-2	4	-9	-29	-37	-11
12/1/04 18:48	11/29/04	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.dm	42	4.00	2	11	1	923	D		-20	-30	-21	-1	3	8	8	22	19	24	-12	-26	8
12/1/04 18:48	11/29/04	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.dm	-50	4.78	2	-11	-1	923	D		-20	-30	-21	-1	3	8	8	22	19	24	-12	-26	8
11/18/04 19:42	11/16/04	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	M.dm	30	4.00	3	7	1	923	D		-21	-30	-24	-16	-12	-4	-3	-2	0	32	1	-34	4
11/18/04 19:42	11/16/04	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.dm	-34	4.57	3	-7	-1	923	D		-21	-30	-24	-16	-12	-4	-3	-2	0	32	1	-34	4
1/30/04 17:48	1/28/04	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.m	-90	9.03	7	-10	-1	923	D		47	77	40	63	19	18	-5	3	-7	-5	-7	-42	-42
1/27/04 17:28	1/23/04	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.m	-102	8.50	5	-12	-1	933	D		43	91	53	73	27	26	12	0	1	-11	-2	-46	-42
1/22/04 18:08	1/20/04	ISIS	Isis Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Crooke Stanley T	CA	DO	CB,P,CEO	S.m	-120	7.76	5	-16	-2	945	D		16	60	34	56	25	15	13	2	9	-2	-5	-43	-39

D	Derivative transaction in filing (usually option exercise)
M	Multiple transactions in filing; earliest reported transaction date and weighted average transaction price
A	Amended filing
E	Error detected in filing

S - Sale	Sale of securities on an exchange or to another person
S - Sale+OE	Sale of securities on an exchange or to another person (after option exercise)
F - Tax	Payment of exercise price or tax liability using portion of securities received from the company
P - Purchase	Purchase of securities on an exchange or from another person

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