12/3/25 21:52 | 12/1/25 | SYRE | Spyre Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Turtle Cameron | MA | DO | CEO | 2 | S | -1,485 | 24.75 | 0 | -60 | | 702 | D | | | | | | | | | | | | | | |
12/3/25 21:19 | 12/2/25 | CORT | Corcept Therapeutics Inc | DE | Health | Drug | Pharmaceutical Preparations | Guyer William | CA | O | Chief De | 19 | S.dm | -17,242 | 69.25 | 0 | -249 | | 6 | M | | | | | | | | | | | | | | |
12/3/25 20:53 | 12/1/25 | CORT | Corcept Therapeutics Inc | DE | Health | Drug | Pharmaceutical Preparations | Maduck Sean | CA | O | See Rema | 14 | S.dm | -27,027 | 79.49 | 0 | -340 | | 118 | D | | | | | | | | | | | | | | |
12/3/25 20:36 | 12/1/25 | CORT | Corcept Therapeutics Inc | DE | Health | Drug | Pharmaceutical Preparations | Lyon Joseph Douglas | CA | O | See Rema | 15 | S.dm | -24,442 | 93.50 | 0 | -261 | | 11 | D | | | | | | | | | | | | | | |
12/3/25 20:23 | 12/2/25 | STOK | Stoke Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Ticho Barry | MA | O | Chief Me | 17 | S.dm | -1,957 | 13.86 | 0 | -141 | | 61 | D | | | | | | | | | | | | | | |
12/3/25 20:22 | 12/2/25 | STOK | Stoke Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Kaye Edward M. Md | MA | D | | 14 | S.dm | -7,115 | 30.55 | 0 | -233 | | 183 | D | | | | | | | | | | | | | | |
12/3/25 20:20 | 11/28/25 | XENE | Xenon Pharmaceuticals Inc. | A1 | Health | Drug | Pharmaceutical Preparations | Mortimer Ian | A1 | DO | P,CEO,IN | 3 | S.dm | -3,222 | 40.23 | 0 | -80 | | 46 | D | | | | | | | | | | | | | | |
12/3/25 20:20 | 12/2/25 | STOK | Stoke Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Allan Jonathan | MA | O | GC,Corp | 8 | S.dm | -1,416 | 17.77 | 0 | -80 | | 35 | D | | | | | | | | | | | | | | |
12/3/25 20:14 | 12/1/25 | CORT | Corcept Therapeutics Inc | DE | Health | Drug | Pharmaceutical Preparations | Belanoff Joseph K | CA | DO | CEO | 11 | S.dm | -25,078 | 78.13 | 0 | -321 | | 3,019 | I | | | | | | | | | | | | | | |
12/3/25 20:11 | 12/1/25 | FOLD | Amicus Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Campbell Bradley L | NJ | DO | P,CEO | 9 | S.d | -801 | 10.69 | 0 | -75 | | 1,151 | D | | | | | | | | | | | | | | |
12/3/25 20:00 | 12/1/25 | JANX | Janux Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Meyer Andrew Hollman | CA | O | Chief Bu | 9 | S.d | -4,195 | 41.95 | 0 | -100 | | 85 | D | | | | | | | | | | | | | | |
12/3/25 19:01 | 12/1/25 | IONS | Ionis Pharmaceuticals Inc | CA | Health | Drug | Pharmaceutical Preparations | Wender Joseph H | CA | D | | 5 | S.m | -8,660 | 67.24 | 0 | -129 | | 109 | I | | | | | | | | | | | | | | |
12/3/25 17:59 | 12/2/25 | MDGL | Madrigal Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Dier Mardi | PA | O | EVP,CFO | 3 | S.d | -3,134 | 490.30 | 0 | -6 | | 10 | D | | | | | | | | | | | | | | |
12/3/25 17:24 | 5/28/25 | ARQT | Arcutis Biotherapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Matsuda Masaru | CA | O | See Rema | 12 | S.d | -1,332 | 15.80 | 0 | -84 | | 209 | D | | | | | | | | | | | | | | |
12/3/25 17:23 | 12/1/25 | ARQT | Arcutis Biotherapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Welgus Howard G. | CA | D | | 17 | S.d | -2,519 | 14.87 | 0 | -169 | | 202 | D | | | | | | | | | | | | | | |
12/3/25 17:11 | 12/1/25 | RPRX | Royalty Pharma Plc | X0 | Health | Drug | Pharmaceutical Preparations | Coyne Terrance P. | NY | O | EVP,CFO | 3 | S | -8,192 | 39.24 | 0 | -209 | | 829 | I | | | | | | | | | | | | | | |
12/3/25 17:10 | 12/1/25 | RPRX | Royalty Pharma Plc | X0 | Health | Drug | Pharmaceutical Preparations | Urist Marshall | NY | O | EVP,Rese | 1 | S | -1,659 | 39.92 | 0 | -42 | | 228 | M | | | | | | | | | | | | | | |
12/3/25 17:09 | 12/2/25 | ENTA | Enanta Pharmaceuticals Inc | | Health | Drug | Pharmaceutical Preparations | Capps Kathleen S. | MA | O | See Rema | 1 | S | -3 | 13.96 | 0 | 0 | | 9 | D | | | | | | | | | | | | | | |
12/3/25 17:08 | 12/1/25 | LGND | Ligand Pharmaceuticals Inc | DE | Health | Drug | Pharmaceutical Preparations | Kozarich John W | FL | D | | 6 | S | -519 | 158.64 | 0 | -3 | | 46 | D | | | | | | | | | | | | | | |
12/3/25 17:05 | 12/2/25 | ENTA | Enanta Pharmaceuticals Inc | | Health | Drug | Pharmaceutical Preparations | Trout Harry R. III | MA | O | See Rema | 1 | S | -5 | 13.96 | 0 | 0 | | 17 | D | | | | | | | | | | | | | | |
12/3/25 17:02 | 12/1/25 | NUVB | Nuvation Bio Inc. | DE | Health | Drug | Pharmaceutical Preparations | Liu Dongfang | NY | O | CHIEF ME | 5 | S.dm | -1,666 | 6.94 | 0 | -240 | | 18 | D | | | | | | | | | | | | | | |
12/3/25 16:39 | 12/1/25 | AMLX | Amylyx Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Bedrosian Camille L | MA | O | Chief Me | 5 | S | -380 | 7.92 | 0 | -48 | | 194 | D | | | | | | | | | | | | | | |
12/3/25 16:30 | 12/1/25 | TVTX | Travere Therapeutics, Inc. | CA | Health | Drug | Pharmaceutical Preparations | Cline Christopher R. | CA | O | CFO | 9 | S.dm | -912 | 28.54 | 0 | -32 | | 93 | D | | | | | | | | | | | | | | |
12/3/25 16:28 | 9/2/25 | CRNX | Crinetics Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Pizzuti Dana | CA | O | Chief Me | 10 | S.d | -3,758 | 40.25 | 0 | -93 | | 96 | D | | | | | | | | | | | | | | |
12/3/25 16:01 | 12/1/25 | INSM | Insmed Inc | VA | Health | Drug | Pharmaceutical Preparations | Flammer Martina M.D. | NJ | O | Chief Me | 14 | S.dm | -61,514 | 106.46 | 0 | -578 | | 138 | D | | | | | | | | | | | | | | |
12/2/25 19:00 | 12/1/25 | GNLX | Genelux Corp | DE | Health | Drug | Pharmaceutical Preparations | Thomas John | CA | D | | 1 | S | -50 | 5.00 | 0 | -10 | | 493 | D | | | | | | | | | | | | | | |
12/2/25 17:14 | 3/20/25 | XERS | Xeris Biopharma Holdings, Inc. | | Health | Drug | Pharmaceutical Preparations | Hecht Beth | IL | O | See Rema | 3 | S | -457 | 6.24 | 0 | -73 | | 1,354 | D | | | | | | | | | | | | | | |
12/2/25 17:14 | 4/15/25 | CYTK | Cytokinetics Inc | | Health | Drug | Pharmaceutical Preparations | Henderson John T | CA | D | | 3 | S.d | -772 | 56.28 | 0 | -14 | | 75 | D | | | | | | | | | | | | | | |
12/2/25 17:10 | 9/9/25 | CYTK | Cytokinetics Inc | | Health | Drug | Pharmaceutical Preparations | Malik Fady Ibraham | CA | O | EVP Rese | 37 | S.d | -7,095 | 50.21 | 0 | -141 | | 141 | D | | | | | | | | | | | | | | |
12/2/25 16:43 | 11/28/25 | PBH | Prestige Consumer Healthcare Inc. | | Health | Drug | Pharmaceutical Preparations | Zerillo Jeffrey | NY | O | SVP Oper | 1 | S.m | -60 | 60.00 | 0 | -1 | | 42 | D | | | | | | | | | | | | | | |
12/2/25 16:34 | 12/1/25 | LQDA | Liquidia Corp | DE | Health | Drug | Pharmaceutical Preparations | Schundler Russell | NC | O | GC | 12 | S.d | -856 | 15.61 | 0 | -55 | | 597 | D | | | | | | | | | | | | | | |
12/2/25 16:33 | 12/1/25 | LQDA | Liquidia Corp | DE | Health | Drug | Pharmaceutical Preparations | Krepp Sarah | NC | O | Chief Hu | 4 | S | -91 | 18.97 | 0 | -5 | | 143 | D | | | | | | | | | | | | | | |
12/2/25 16:32 | 12/1/25 | UTHR | United Therapeutics Corp | DE | Health | Drug | Pharmaceutical Preparations | Edgemond James | MD | O | CFO,TREA | 19 | S.d | -89,414 | 401.76 | 0 | -223 | | 8 | D | | | | | | | | | | | | | | |
12/2/25 16:32 | 12/1/25 | LQDA | Liquidia Corp | DE | Health | Drug | Pharmaceutical Preparations | Kaseta Michael | NC | O | CFO,COO | 14 | S.d | -2,365 | 18.23 | 0 | -130 | | 412 | D | | | | | | | | | | | | | | |
12/2/25 16:32 | 8/26/24 | UTHR | United Therapeutics Corp | DE | Health | Drug | Pharmaceutical Preparations | Rothblatt Martine A | MD | DO | CHAIRPER | 47 | S.edm | -139,991 | 405.69 | 0 | -345 | | 646 | D | | | | | | | | | | | | | | |
12/2/25 16:31 | 12/1/25 | LQDA | Liquidia Corp | DE | Health | Drug | Pharmaceutical Preparations | Boyle Dana | NC | O | Chief Ac | 7 | S | -837 | 24.51 | 0 | -34 | | 187 | D | | | | | | | | | | | | | | |
12/2/25 16:31 | 12/1/25 | UTHR | United Therapeutics Corp | DE | Health | Drug | Pharmaceutical Preparations | Benkowitz Michael | MD | O | P,COO | 35 | S.dm | -222,477 | 404.32 | 0 | -550 | | 3 | I | | | | | | | | | | | | | | |
12/2/25 16:31 | 12/1/25 | LQDA | Liquidia Corp | DE | Health | Drug | Pharmaceutical Preparations | Adair Jason | NC | O | Chief Bu | 20 | S.dm | -2,203 | 25.29 | 0 | -87 | | 194 | D | | | | | | | | | | | | | | |
12/2/25 16:30 | 8/25/25 | NUVL | Nuvalent, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Noci Darlene | MA | O | Chief De | 15 | S.dm | -7,513 | 79.91 | 0 | -94 | | 48 | D | | | | | | | | | | | | | | |
12/2/25 16:30 | 12/1/25 | LQDA | Liquidia Corp | DE | Health | Drug | Pharmaceutical Preparations | Moomaw Scott | NC | O | Chief Co | 12 | S.d | -2,539 | 24.54 | 0 | -103 | | 225 | D | | | | | | | | | | | | | | |
12/2/25 16:15 | 9/9/25 | PAHC | Phibro Animal Health Corp | DE | Health | Drug | Pharmaceutical Preparations | Bendheim Jack | NJ | DOT | P,CEO | 13 | S.dm | -8,855 | 42.64 | 0 | -208 | | 91 | I | | | | | | | | | | | | | | |
12/2/25 16:04 | 12/1/25 | MIRM | Mirum Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Grey Michael G | CA | D | | 2 | S.d | -7,200 | 72.00 | 0 | -100 | | 280 | D | | | | | | | | | | | | | | |
12/2/25 09:13 | 9/2/25 | CYTK | Cytokinetics Inc | | Health | Drug | Pharmaceutical Preparations | Harrington Robert Arthur | CA | D | | 4 | S | -304 | 53.85 | 0 | -6 | | 20 | D | | | | | | | | | | | | | | |
12/1/25 19:02 | 11/26/25 | TBPH | Theravance Biopharma, Inc. | CA | Health | Drug | Pharmaceutical Preparations | Broshy Eran | CA | D | | 3 | S.d | -2,468 | 18.48 | 0 | -134 | | 60 | D | | | | | | | | | | | | | | |
12/1/25 18:14 | 2/3/25 | JAZZ | Jazz Pharmaceuticals Plc | L2 | Health | Drug | Pharmaceutical Preparations | Cozadd Bruce C | L2 | D | | 14 | S.dm | -20,916 | 166.66 | 0 | -126 | | 464 | D | | | | | | | | | | | | | | |
12/1/25 18:13 | 3/27/25 | HOWL | Werewolf Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Evnin Luke | MA | D | | 9 | S.dm | -1,312 | 1.18 | 0 | -1,116 | | 4,310 | I | | | | | | | | | | | | | | |
12/1/25 18:12 | 3/27/25 | HOWL | Werewolf Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Mpm Bioventures 2014, L.P. | MA | T | | 10 | S.dm | -2,959 | 1.66 | 0 | -1,782 | | 10,824 | I | | | | | | | | | | | | | | |
12/1/25 18:11 | 3/27/25 | HOWL | Werewolf Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Gadicke Ansbert | MA | T | | 9 | S.dm | -2,045 | 1.18 | 0 | -1,739 | | 6,719 | I | | | | | | | | | | | | | | |
12/1/25 18:10 | 11/28/25 | ARWR | Arrowhead Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Ferrari Mauro | CA | D | | 1 | S | -493 | 56.39 | 0 | -9 | | 69 | D | | | | | | | | | | | | | | |
12/1/25 18:09 | 11/26/25 | RCUS | Arcus Biosciences, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Azoy Alexander | CA | O | Chief Ac | 5 | S.d | -128 | 16.31 | 0 | -8 | | 30 | D | | | | | | | | | | | | | | |
12/1/25 17:41 | 12/1/25 | ALKS | Alkermes Plc. | | Health | Drug | Pharmaceutical Preparations | Hopkinson Craig C. | MA | O | EVP R,D, | 10 | S.dm | -20,535 | 32.78 | 0 | -626 | | 99 | D | | | | | | | | | | | | | | |
12/1/25 16:57 | 11/26/25 | ONC | Beone Medicines Ltd. | | Health | Drug | Pharmaceutical Preparations | Sanders Corazon (Corsee) D. | V8 | D | | 3 | S.d | -1,884 | 244.71 | 0 | -8 | | 73 | D | | | | | | | | | | | | | | |
12/1/25 16:40 | 11/26/25 | VSTM | Verastem, Inc. | MA | Health | Drug | Pharmaceutical Preparations | Paterson Dan | MA | DO | P,CEO | 17 | S.m | -808 | 7.39 | 0 | -109 | | 462 | D | | | | | | | | | | | | | | |
12/1/25 16:37 | 11/26/25 | KNSA | Kiniksa Pharmaceuticals International, Plc | X0 | Health | Drug | Pharmaceutical Preparations | Tessari Eben | X0 | O | COO | 22 | S.dm | -19,127 | 31.08 | 0 | -615 | | 120 | D | | | | | | | | | | | | | | |
12/1/25 16:17 | 9/8/25 | RAPP | Rapport Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Gault Cheryl | MA | O | COO | 2 | S.d | -342 | 34.21 | 0 | -10 | | 172 | D | | | | | | | | | | | | | | |
12/1/25 16:07 | 11/26/25 | CVRX | Cvrx, Inc. | NJ | Health | Drug | Pharmaceutical Preparations | Johnson & Johnson | NJ | T | | 4 | S.m | -637 | 10.18 | 0 | -63 | | 4,051 | I | | | | | | | | | | | | | | |
12/1/25 16:02 | 11/26/25 | TEVA | Teva Pharmaceutical Industries Ltd | L3 | Health | Drug | Pharmaceutical Preparations | Mignone Roberto | L3 | D | | 3 | S | -12,417 | 23.17 | 0 | -536 | | 791 | I | | | | | | | | | | | | | | |
11/28/25 17:51 | 11/25/25 | IONS | Ionis Pharmaceuticals Inc | CA | Health | Drug | Pharmaceutical Preparations | Klein Joseph III | CA | D | | 3 | S.d | -4,320 | 63.53 | 0 | -68 | | 16 | I | | | | | | | | | | | | | | |
11/28/25 17:51 | 11/25/25 | IONS | Ionis Pharmaceuticals Inc | CA | Health | Drug | Pharmaceutical Preparations | Devers Shannon L. | CA | O | EVP,Chie | 4 | S.dm | -2,221 | 70.57 | 0 | -31 | | 17 | D | | | | | | | | | | | | | | |
11/28/25 17:00 | 11/26/25 | CPRX | Catalyst Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Del Carmen Jeffrey | FL | O | Chief Co | 3 | S.d | -1,617 | 20.87 | 0 | -77 | | 12 | D | | | | | | | | | | | | | | |
11/28/25 16:05 | 11/25/25 | MRUS | Merus N.V. | P7 | Health | Drug | Pharmaceutical Preparations | Shuman Harry | P7 | O | VP Contr | 3 | S.dm | -1,260 | 72.84 | 0 | -17 | | 11 | D | | | | | | | | | | | | | | |
11/26/25 21:30 | 11/24/25 | CRMD | Cormedix Inc. | DE | Health | Drug | Pharmaceutical Preparations | Dillione Janet | NJ | D | | 2 | S.d | -604 | 10.72 | 0 | -56 | | 48 | D | | | | | | | | | | | | | | |
11/26/25 21:18 | 11/24/25 | FOLD | Amicus Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Castelli Jeff | NJ | O | Chief De | 1 | S.d | -774 | 10.16 | 0 | -76 | | 439 | D | | | | | | | | | | | | | | |
11/26/25 21:17 | 11/24/25 | FOLD | Amicus Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Clark David Michael | NJ | O | Chief Pe | 2 | S | -503 | 9.80 | 0 | -51 | | 323 | D | | | | | | | | | | | | | | |
11/26/25 21:16 | 11/24/25 | FOLD | Amicus Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Rosenberg Ellen | NJ | O | GC | 1 | S.dm | -958 | 10.02 | 0 | -96 | | 523 | D | | | | | | | | | | | | | | |
11/26/25 18:50 | 11/24/25 | KALV | Kalvista Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Piekos Brian | MA | O | CFO | 1 | S.d | -60 | 13.45 | 0 | -4 | | 11 | D | | | | | | | | | | | | | | |
11/26/25 18:49 | 11/24/25 | KALV | Kalvista Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Yea Christopher | MA | O | CHIEF DE | 15 | S.d | -984 | 13.34 | 0 | -74 | | 224 | D | | | | | | | | | | | | | | |
11/26/25 18:47 | 11/24/25 | KALV | Kalvista Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Audhya Paul K. | MA | O | CHIEF ME | 14 | S.d | -587 | 11.72 | 0 | -50 | | 132 | D | | | | | | | | | | | | | | |
11/26/25 18:46 | 9/8/25 | KALV | Kalvista Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Palleiko Benjamin L | MA | DO | CEO | 16 | S.d | -1,952 | 12.95 | 0 | -151 | | 416 | D | | | | | | | | | | | | | | |
11/26/25 18:45 | 11/24/25 | IRON | Disc Medicine, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Orbimed Advisors LLC | NY | D | | 10 | S.dm | -55,823 | 12.81 | 0 | -4,357 | | 25,423 | I | | | | | | | | | | | | | | |
11/26/25 18:41 | 11/24/25 | SION | Sionna Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Thompson Peter A. | MA | D | | 4 | S.dm | -22,292 | 9.97 | 0 | -2,237 | | 19,134 | I | | | | | | | | | | | | | | |
11/26/25 18:24 | 11/24/25 | ORGO | Organogenesis Holdings Inc. | DE | Health | Drug | Pharmaceutical Preparations | Nussdorf Glenn H | NY | DT | | 2 | S.m | -1,673 | 5.18 | 0 | -323 | | 12,249 | D | | | | | | | | | | | | | | |
11/26/25 17:21 | 8/18/25 | SER | Serina Therapeutics, Inc. | AL | Health | Drug | Pharmaceutical Preparations | Moreadith Randall | AL | O | Chief Sc | 20 | S.dm | -810 | 5.66 | 0 | -143 | | 6 | D | | | | | | | | | | | | | | |
11/26/25 16:31 | 11/24/25 | INSM | Insmed Inc | VA | Health | Drug | Pharmaceutical Preparations | Anderson Elizabeth M | NJ | D | | 2 | S | -2,982 | 198.77 | 0 | -15 | | 64 | D | | | | | | | | | | | | | | |
11/26/25 16:30 | 8/21/25 | UTHR | United Therapeutics Corp | DE | Health | Drug | Pharmaceutical Preparations | Mahon Paul A | MD | O | EVP,GC | 20 | S.d | -75,468 | 353.65 | 0 | -213 | | 37 | D | | | | | | | | | | | | | | |
11/26/25 16:30 | 11/25/25 | ADTX | Aditxt, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Pankovcin Corinne | CA | O | Chief M, | 1 | S | 0 | 3.00 | 0 | 0 | -100 | 0 | D | | | | | | | | | | | | | | |
11/26/25 16:30 | 11/24/25 | NUVL | Nuvalent, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Shair Matthew | MA | D | | 10 | S.m | -8,235 | 98.63 | 0 | -84 | | 1,658 | M | | | | | | | | | | | | | | |
11/26/25 16:07 | 12/31/24 | RCUS | Arcus Biosciences, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Goeltz II Robert C. | CA | O | CFO | 3 | S | -279 | 20.52 | 0 | -14 | | 92 | D | | | | | | | | | | | | | | |
11/26/25 16:06 | 11/24/25 | STOK | Stoke Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Krainer Adrian R. | MA | D | | 2 | S | -2,295 | 28.35 | 0 | -81 | | 364 | D | | | | | | | | | | | | | | |
11/26/25 16:02 | 11/24/25 | OCUL | Ocular Therapeutix, Inc | DE | Health | Drug | Pharmaceutical Preparations | Nayak Sanjay | MA | O | Chief St | 6 | S | -104 | 9.36 | 0 | -11 | | 283 | D | | | | | | | | | | | | | | |
11/26/25 16:02 | 11/24/25 | OCUL | Ocular Therapeutix, Inc | DE | Health | Drug | Pharmaceutical Preparations | Dugel Pravin | MA | DO | See Rema | 6 | S | -1,168 | 9.33 | 0 | -125 | | 3,520 | M | | | | | | | | | | | | | | |
11/26/25 16:01 | 11/24/25 | OCUL | Ocular Therapeutix, Inc | DE | Health | Drug | Pharmaceutical Preparations | Kaiser Peter | MA | O | Chief De | 6 | S | -247 | 10.06 | 0 | -25 | | 213 | D | | | | | | | | | | | | | | |
11/26/25 16:01 | 11/24/25 | OCUL | Ocular Therapeutix, Inc | DE | Health | Drug | Pharmaceutical Preparations | Heier Jeffrey S. | MA | O | Chief Sc | 6 | S | -264 | 10.12 | 0 | -26 | | 269 | D | | | | | | | | | | | | | | |
11/26/25 16:00 | 7/24/25 | LLY | Eli Lilly & Co | IN | Health | Drug | Pharmaceutical Preparations | Lilly Endowment Inc | IN | T | | 42 | S.e | -3,070,340 | 646.82 | 0 | -4,747 | | 96,941 | D | | | | | | | | | | | | | | |
11/25/25 20:30 | 11/25/25 | NKTR | Nektar Therapeutics | DE | Health | Drug | Pharmaceutical Preparations | Zalevsky Jonathan | CA | O | Chief R, | 9 | S.d | -237 | 2.60 | 0 | -91 | | 327 | D | | | | | | | | | | | | | | |
11/25/25 20:29 | 11/25/25 | NKTR | Nektar Therapeutics | DE | Health | Drug | Pharmaceutical Preparations | Wilson Mark Andrew | CA | O | GC | 7 | S.dm | -129 | 1.52 | 0 | -84 | | 335 | D | | | | | | | | | | | | | | |
11/25/25 20:28 | 11/25/25 | NKTR | Nektar Therapeutics | DE | Health | Drug | Pharmaceutical Preparations | Robin Howard W | CA | DO | P,CEO | 10 | S.dm | -1,156 | 4.94 | 0 | -234 | | 1,111 | D | | | | | | | | | | | | | | |
11/25/25 19:38 | 12/9/24 | AMPH | Amphastar Pharmaceuticals, Inc. | | Health | Drug | Pharmaceutical Preparations | Prins Richard K | CA | D | | 4 | S.d | -1,531 | 42.21 | 0 | -36 | | 35 | D | | | | | | | | | | | | | | |
11/25/25 18:42 | 11/21/25 | BCAX | Bicara Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | Hyep Ivan | MA | O | CFO | 3 | S.dm | -1,011 | 18.32 | 0 | -55 | | 145 | D | | | | | | | | | | | | | | |
11/25/25 18:41 | 11/21/25 | BCAX | Bicara Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | Cohlhepp Ryan | MA | DO | P,COO | 3 | S.dm | -1,364 | 18.07 | 0 | -76 | | 203 | D | | | | | | | | | | | | | | |
11/25/25 18:40 | 11/24/25 | BCAX | Bicara Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | Mazumdar Claire | MA | DO | CEO | 3 | S.dm | -1,697 | 18.86 | 0 | -90 | | 310 | D | | | | | | | | | | | | | | |
11/25/25 18:39 | 11/24/25 | BCAX | Bicara Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | Raben David | MA | O | Chief Me | 2 | S.dm | -611 | 18.52 | 0 | -33 | | 35 | D | | | | | | | | | | | | | | |
11/25/25 18:27 | 11/24/25 | ARQT | Arcutis Biotherapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Lin Sue-Jean | CA | D | | 1 | S.d | -778 | 30.78 | 0 | -25 | | 27 | D | | | | | | | | | | | | | | |
11/25/25 18:08 | 11/25/25 | EQ | Equillium, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Zedelmayer Christine | CA | O | SVP,COO | 2 | S | -26 | 1.14 | 0 | -23 | | 135 | D | | | | | | | | | | | | | | |
11/25/25 17:35 | 11/21/25 | VSTM | Verastem, Inc. | MA | Health | Drug | Pharmaceutical Preparations | Bunn Paul A. | MA | D | | 2 | S.d | -138 | 9.46 | 0 | -15 | | 8 | D | | | | | | | | | | | | | | |
11/25/25 17:34 | 11/21/25 | VSTM | Verastem, Inc. | MA | Health | Drug | Pharmaceutical Preparations | Kauffman Michael | MA | D | | 1 | S | -86 | 10.00 | 0 | -9 | | 9 | D | | | | | | | | | | | | | | |
11/25/25 17:31 | 11/24/25 | TGTX | Tg Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Echelard Yann | NC | D | | 3 | S | -1,022 | 29.20 | 0 | -35 | | 229 | D | | | | | | | | | | | | | | |
11/25/25 17:00 | 11/21/25 | TYRA | Tyra Biosciences, Inc. | DE | Health | Drug | Pharmaceutical Preparations | More Robert J | CA | D | | 1 | S | -5,000 | 20.25 | 0 | -247 | | 3,833 | I | | | | | | | | | | | | | | |
11/25/25 16:44 | 8/21/25 | ARDX | Ardelyx, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Grammer Elizabeth A | MA | O | See Rema | 6 | S | -192 | 5.29 | 0 | -36 | | 312 | D | | | | | | | | | | | | | | |
11/25/25 16:42 | 8/21/25 | ARDX | Ardelyx, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Raab Michael | MA | DO | P,CEO | 21 | S.d | -3,139 | 5.26 | 0 | -597 | | 1,661 | D | | | | | | | | | | | | | | |
11/25/25 16:38 | 8/21/25 | ARDX | Ardelyx, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Kelliher Mike | MA | O | Chief Bu | 3 | S | -122 | 4.79 | 0 | -25 | | 282 | D | | | | | | | | | | | | | | |
11/25/25 16:35 | 8/26/25 | ARDX | Ardelyx, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Williams Laura A | MA | O | Chief Pa | 7 | S.d | -695 | 5.85 | 0 | -119 | | 403 | D | | | | | | | | | | | | | | |
11/25/25 16:22 | 8/21/25 | ARDX | Ardelyx, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Foster Eric Duane | MA | O | Chief Co | 3 | S | -133 | 5.64 | 0 | -24 | | 317 | D | | | | | | | | | | | | | | |
11/25/25 16:21 | 11/21/25 | ARDX | Ardelyx, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Reilly Joseph James | MA | O | See Rema | 1 | S | -61 | 5.54 | 0 | -11 | | 109 | D | | | | | | | | | | | | | | |
11/25/25 16:17 | 11/25/25 | ABT | Abbott Laboratories | IL | Health | Drug | Pharmaceutical Preparations | Shroff Eric | IL | O | SVP | 2 | S | -281 | 130.68 | 0 | -2 | | 32 | D | | | | | | | | | | | | | | |
11/25/25 16:11 | 11/21/25 | ZLAB | Zai Lab Ltd | E9 | Health | Drug | Pharmaceutical Preparations | Edmondson Frazor Titus III | MA | O | GC | 7 | S.d | -1,295 | 28.91 | 0 | -45 | | 42 | D | | | | | | | | | | | | | | |
11/25/25 16:10 | 11/21/25 | HRMY | Harmony Biosciences Holdings, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Kapadia Sandip | PA | O | CFO | 5 | S.d | -2,207 | 37.56 | 0 | -59 | -100 | 0 | D | | | | | | | | | | | | | | |
11/25/25 16:05 | 11/21/25 | VERA | Vera Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Carter Jason S | CA | O | GC | 1 | S | -107 | 27.82 | 0 | -4 | | 49 | D | | | | | | | | | | | | | | |
11/24/25 20:00 | 11/24/25 | NUVL | Nuvalent, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Flynn James E | NY | DTH | Director | 4 | S.m | -290,182 | 71.72 | 0 | -4,046 | | 28,506 | I | | | | | | | | | | | | | | |
11/24/25 18:46 | 9/4/25 | BBIO | Bridgebio Pharma, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Kumar Neil | CA | DO | CEO | 15 | S.dm | -59,055 | 40.32 | 0 | -1,465 | | 6,906 | I | | | | | | | | | | | | | | |
11/24/25 18:45 | 11/21/25 | ARQT | Arcutis Biotherapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Watanabe Todd | CA | DO | See Rema | 14 | S.dm | -5,342 | 19.62 | 0 | -272 | | 1,161 | D | | | | | | | | | | | | | | |
11/24/25 18:06 | 11/24/25 | NRIX | Nurix Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Ring Christine | CA | O | GC | 17 | S.d | -2,374 | 20.06 | 0 | -118 | | 51 | D | | | | | | | | | | | | | | |
11/24/25 17:47 | 11/20/25 | JAZZ | Jazz Pharmaceuticals Plc | L2 | Health | Drug | Pharmaceutical Preparations | McSharry Heather Ann | L2 | D | | 1 | S.d | -607 | 177.78 | 0 | -3 | | 20 | D | | | | | | | | | | | | | | |
11/24/25 17:43 | 8/9/24 | ANTX | An2 Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Ra Capital Management, L.P. | MA | T | | 4 | S.m | -25,271 | 6.22 | 0 | -4,065 | | 510 | I | | | | | | | | | | | | | | |
11/24/25 16:42 | 8/16/24 | GRTX | Galera Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Sorensen Mel | PA | DO | P,CEO | 2 | S | -6 | 0.0455 | 0 | -137 | | 265 | D | | | | | | | | | | | | | | |
11/24/25 16:30 | 11/21/25 | TRDA | Entrada Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Wentworth Kory James | MA | O | CFO | 5 | S.dm | -448 | 15.72 | 0 | -29 | | 110 | D | | | | | | | | | | | | | | |
11/24/25 16:15 | 11/20/25 | RYTM | Rhythm Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Cramer Pamela J. | MA | O | CHRO | 15 | S.dm | -9,514 | 64.37 | 0 | -148 | | 32 | D | | | | | | | | | | | | | | |
11/24/25 16:09 | 11/20/25 | NUVB | Nuvation Bio Inc. | DE | Health | Drug | Pharmaceutical Preparations | Hattersley Gary | NY | O | Chief Sc | 2 | S.d | -3,170 | 6.76 | 0 | -469 | -100 | 0 | D | | | | | | | | | | | | | | |
11/24/25 16:05 | 8/15/24 | REGN | Regeneron Pharmaceuticals, Inc. | NY | Health | Drug | Pharmaceutical Preparations | Bassler Bonnie L | NY | D | | 3 | S.d | -2,297 | 1,011.2 | 0 | -2 | | 2 | D | | | | | | | | | | | | | | |
11/24/25 16:03 | 11/20/25 | TEVA | Teva Pharmaceutical Industries Ltd | L3 | Health | Drug | Pharmaceutical Preparations | Fox Christine | L3 | O | EVP,Head | 4 | S.dm | -1,878 | 22.41 | 0 | -84 | | 64 | D | | | | | | | | | | | | | | |
11/21/25 21:41 | 11/20/25 | PRAX | Praxis Precision Medicines, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Nemiroff Alex | MA | O | GC,Secre | 2 | S.d | -5,513 | 165.22 | 0 | -33 | | 21 | D | | | | | | | | | | | | | | |
11/21/25 21:39 | 11/20/25 | PRAX | Praxis Precision Medicines, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Mastrocola Lauren | MA | O | Principa | 2 | S.d | -3,037 | 161.62 | 0 | -19 | | 10 | D | | | | | | | | | | | | | | |
11/21/25 20:24 | 8/14/24 | ROIV | Roivant Sciences Ltd. | D0 | Health | Drug | Pharmaceutical Preparations | Manchester Keith S | X0 | D | | 3 | S.dm | -32,203 | 17.77 | 0 | -1,812 | | 18,094 | D | | | | | | | | | | | | | | |
11/21/25 20:22 | 11/19/25 | ROIV | Roivant Sciences Ltd. | D0 | Health | Drug | Pharmaceutical Preparations | Gold Daniel Allen | X0 | D | | 2 | S.m | -78,125 | 13.64 | 0 | -5,726 | | 28,625 | I | | | | | | | | | | | | | | |
11/21/25 20:15 | 11/19/25 | ROIV | Roivant Sciences Ltd. | D0 | Health | Drug | Pharmaceutical Preparations | Qvt Financial LP | NY | H | Director | 2 | S.m | -37,247 | 16.73 | 0 | -2,226 | | 65,794 | I | | | | | | | | | | | | | | |
11/21/25 19:54 | 11/19/25 | PGEN | Precigen, Inc. | VA | Health | Drug | Pharmaceutical Preparations | Kirk Randal J | VA | DT | | 3 | S.dm | -37,116 | 3.80 | 0 | -9,776 | | 128,722 | I | | | | | | | | | | | | | | |
11/21/25 18:21 | 11/20/25 | ARQT | Arcutis Biotherapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Gilbert Halley E | CA | D | | 1 | S.d | -455 | 27.55 | 0 | -17 | | 22 | D | | | | | | | | | | | | | | |
11/21/25 18:13 | 11/20/25 | SGMT | Sagimet Biosciences Inc. | DE | Health | Drug | Pharmaceutical Preparations | Kemble George | CA | DO | Exec CB | 3 | S | -408 | 5.42 | 0 | -75 | | 142 | D | | | | | | | | | | | | | | |
11/21/25 18:07 | 11/20/25 | MLYS | Mineralys Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Slingsby Brian Taylor | WA | DT | | 2 | S | -50,528 | 32.60 | 0 | -1,550 | | 8,645 | I | | | | | | | | | | | | | | |
11/21/25 17:39 | 11/21/25 | MDGL | Madrigal Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Huntsman Carole | PA | O | Chief Co | 4 | S | -2,015 | 417.48 | 0 | -5 | | 11 | D | | | | | | | | | | | | | | |
11/21/25 17:28 | 11/19/25 | ELVN | Enliven Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Lyssikatos Joseph P | CO | O | CHIEF SC | 20 | S.m | -4,751 | 23.48 | 0 | -202 | | 1,093 | I | | | | | | | | | | | | | | |
11/21/25 16:59 | 11/19/25 | LFVN | Lifevantage Corp | | Health | Drug | Pharmaceutical Preparations | Beindorff Michael A | UT | D | | 4 | S | -494 | 8.41 | 0 | -59 | | 124 | I | | | | | | | | | | | | | | |
11/21/25 16:55 | 11/19/25 | RPRX | Royalty Pharma Plc | X0 | Health | Drug | Pharmaceutical Preparations | Lloyd George W. | NY | O | EVP,Inve | 1 | S | -5,193 | 38.34 | 0 | -135 | | 1,000 | M | | | | | | | | | | | | | | |
11/21/25 16:25 | 11/19/25 | PVLA | Palvella Therapeutics, Inc. | NV | Health | Drug | Pharmaceutical Preparations | Goin Kathleen | PA | O | COO | 1 | S.d | -371 | 86.23 | 0 | -4 | -100 | 0 | D | | | | | | | | | | | | | | |
11/21/25 16:15 | 11/19/25 | FULC | Fulcrum Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Gould Robert J | MA | D | | 1 | S | -165 | 11.03 | 0 | -15 | | 485 | D | | | | | | | | | | | | | | |
11/21/25 16:05 | 11/19/25 | NUVB | Nuvation Bio Inc. | DE | Health | Drug | Pharmaceutical Preparations | Hanley David C. | NY | O | CHIEF TE | 1 | S.d | -1,428 | 7.14 | 0 | -200 | | 24 | D | | | | | | | | | | | | | | |
11/20/25 18:13 | 11/18/25 | JAZZ | Jazz Pharmaceuticals Plc | L2 | Health | Drug | Pharmaceutical Preparations | Carr Patricia | L2 | O | SVP,Chie | 4 | S.dm | -1,938 | 160.18 | 0 | -12 | | 9 | D | | | | | | | | | | | | | | |
11/20/25 17:54 | 11/18/25 | JAZZ | Jazz Pharmaceuticals Plc | L2 | Health | Drug | Pharmaceutical Preparations | Winningham Rick E | L2 | D | | 1 | S | -995 | 180.86 | 0 | -6 | | 9 | D | | | | | | | | | | | | | | |
11/20/25 17:12 | 11/19/25 | IONS | Ionis Pharmaceuticals Inc | CA | Health | Drug | Pharmaceutical Preparations | Herman Joan E | CA | D | | 1 | S.d | -3,174 | 72.13 | 0 | -44 | | 46 | D | | | | | | | | | | | | | | |
11/20/25 16:05 | 11/18/25 | RCKT | Rocket Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Schwartz Jonathan David | NJ | O | See Rema | 6 | S.m | -288 | 8.56 | 0 | -34 | | 299 | D | | | | | | | | | | | | | | |
11/20/25 16:05 | 11/18/25 | RCKT | Rocket Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Shah Gaurav | NJ | DO | CEO | 6 | S | -553 | 11.24 | 0 | -49 | | 1,195 | D | | | | | | | | | | | | | | |
11/20/25 16:05 | 11/18/25 | RCKT | Rocket Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Militello John | NJ | O | See Rema | 13 | S.m | -262 | 5.51 | 0 | -47 | | 67 | D | | | | | | | | | | | | | | |
11/20/25 16:05 | 11/18/25 | RCKT | Rocket Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Wilson Martin | NJ | O | GC | 8 | S.m | -125 | 5.59 | 0 | -22 | | 384 | D | | | | | | | | | | | | | | |
11/20/25 13:42 | 11/19/25 | URGN | Urogen Pharma Ltd. | L3 | Health | Drug | Pharmaceutical Preparations | Schoenberg Mark | NJ | O | Chief Me | 7 | S.d | -642 | 17.55 | 0 | -37 | | 158 | D | | | | | | | | | | | | | | |
11/19/25 20:31 | 3/10/25 | JAZZ | Jazz Pharmaceuticals Plc | L2 | Health | Drug | Pharmaceutical Preparations | Iannone Robert | L2 | O | EVP,Glob | 3 | S | -2,518 | 151.33 | 0 | -17 | | 82 | D | | | | | | | | | | | | | | |
11/19/25 19:30 | 11/18/25 | TYRA | Tyra Biosciences, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Bensen Daniel | CA | O | COO | 2 | S.m | -4,139 | 16.11 | 0 | -257 | | 297 | D | | | | | | | | | | | | | | |
11/19/25 18:57 | 9/9/24 | CYTK | Cytokinetics Inc | | Health | Drug | Pharmaceutical Preparations | Parshall B Lynne | CA | D | | 8 | S.d | -3,046 | 55.39 | 0 | -55 | | 109 | D | | | | | | | | | | | | | | |
11/19/25 18:45 | 11/17/25 | ELVN | Enliven Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Kintz Samuel | CO | DO | P,CEO | 21 | S.m | -4,251 | 22.96 | 0 | -185 | | 1,241 | I | | | | | | | | | | | | | | |
11/19/25 18:28 | 11/12/25 | NATR | Natures Sunshine Products Inc | UT | Health | Drug | Pharmaceutical Preparations | Norman Daniel C | UT | O | EVP,P,As | 1 | S | -182 | 20.46 | 0 | -9 | | 63 | D | | | | | | | | | | | | | | |
11/19/25 18:00 | 11/18/25 | ACAD | Acadia Pharmaceuticals Inc | DE | Health | Drug | Pharmaceutical Preparations | Schneyer Mark C. | CA | O | EVP,CFO | 10 | S.d | -1,412 | 20.79 | 0 | -68 | | 63 | D | | | | | | | | | | | | | | |
11/19/25 18:00 | 11/18/25 | ACAD | Acadia Pharmaceuticals Inc | DE | Health | Drug | Pharmaceutical Preparations | Kihara James | CA | O | PRINCIPA | 7 | S.d | -318 | 19.77 | 0 | -16 | | 25 | D | | | | | | | | | | | | | | |
11/19/25 17:24 | 11/18/25 | NATR | Natures Sunshine Products Inc | UT | Health | Drug | Pharmaceutical Preparations | Lanoy Jonathan David | UT | O | SVP,Chie | 2 | S | -185 | 18.48 | 0 | -10 | | 50 | D | | | | | | | | | | | | | | |
11/19/25 17:14 | 11/17/25 | NUVL | Nuvalent, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Balcom Alexandra | MA | O | CFO | 13 | S.dm | -17,871 | 87.60 | 0 | -204 | | 62 | D | | | | | | | | | | | | | | |
11/19/25 17:13 | 11/17/25 | NUVL | Nuvalent, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Miller Deborah Ann | MA | O | GC | 9 | S.dm | -10,231 | 95.65 | 0 | -107 | | 49 | D | | | | | | | | | | | | | | |
11/19/25 17:08 | 11/17/25 | BBIO | Bridgebio Pharma, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Lo Andrew | CA | D | | 2 | S.m | -10,170 | 51.99 | 0 | -196 | | 154 | M | | | | | | | | | | | | | | |
11/19/25 17:06 | 11/17/25 | BBIO | Bridgebio Pharma, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Scott Randal W. | CA | D | | 1 | S.d | -666 | 66.65 | 0 | -10 | | 16 | D | | | | | | | | | | | | | | |
11/19/25 16:57 | 11/17/25 | ONC | Beone Medicines Ltd. | | Health | Drug | Pharmaceutical Preparations | Wu Xiaobin | V8 | O | P,COO | 14 | S.dm | -78,856 | 280.05 | 0 | -282 | | 1,262 | D | | | | | | | | | | | | | | |
11/19/25 16:39 | 11/17/25 | RCUS | Arcus Biosciences, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Jaen Juan C. | CA | O | P | 3 | S.m | -3,111 | 20.58 | 0 | -151 | | 1,459 | I | | | | | | | | | | | | | | |
11/19/25 16:32 | 11/17/25 | PCRX | Pacira Biosciences, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Slonin Jonathan | CA | O | Chief Me | 3 | S | -131 | 22.57 | 0 | -6 | | 178 | D | | | | | | | | | | | | | | |
11/19/25 16:21 | 11/17/25 | AMRX | Amneal Pharmaceuticals, Inc. | | Health | Drug | Pharmaceutical Preparations | Nark Ted C | NJ | D | | 1 | S | -586 | 11.72 | 0 | -50 | | 291 | D | | | | | | | | | | | | | | |
11/19/25 16:06 | 11/17/25 | VRTX | Vertex Pharmaceuticals Inc / Ma | MA | Health | Drug | Pharmaceutical Preparations | Atkinson Edward Morrow III | MA | O | EVP,Chie | 4 | S | -3,999 | 461.60 | 0 | -9 | | 24 | D | | | | | | | | | | | | | | |
11/19/25 16:06 | 11/17/25 | CYPH | Cypherpunk Technologies Inc. | DE | Health | Drug | Pharmaceutical Preparations | Mirabelli Christopher | MA | D | | 1 | S | -2,124 | 3.14 | 0 | -676 | | 23 | I | | | | | | | | | | | | | | |
11/19/25 16:05 | 11/17/25 | CYPH | Cypherpunk Technologies Inc. | DE | Health | Drug | Pharmaceutical Preparations | Cavanaugh James H | MA | D | | 1 | S | -822 | 3.14 | 0 | -262 | -100 | 0 | I | | | | | | | | | | | | | | |
11/19/25 16:05 | 11/17/25 | ALNY | Alnylam Pharmaceuticals, Inc. | | Health | Drug | Pharmaceutical Preparations | Fitzgerald Kevin Joseph | MA | O | CSO,EVP, | 8 | S.dm | -15,264 | 329.37 | 0 | -46 | | 26 | D | | | | | | | | | | | | | | |
11/19/25 16:05 | 11/17/25 | CYPH | Cypherpunk Technologies Inc. | DE | Health | Drug | Pharmaceutical Preparations | Onsi Douglas E | MA | DO | CEO,CFO, | 1 | S | -2,124 | 3.14 | 0 | -676 | | 108 | I | | | | | | | | | | | | | | |
11/19/25 16:05 | 11/17/25 | IRWD | Ironwood Pharmaceuticals Inc | DE | Health | Drug | Pharmaceutical Preparations | Gaskins Tammi L | MA | O | Chief Co | 3 | S | -23 | 2.28 | 0 | -10 | | 243 | D | | | | | | | | | | | | | | |
11/19/25 16:01 | 11/17/25 | GALT | Galectin Therapeutics Inc | NV | Health | Drug | Pharmaceutical Preparations | Lewis Joel | GA | DO | P,CEO | 6 | S.dm | -383 | 3.47 | 0 | -110 | | 899 | D | | | | | | | | | | | | | | |
11/19/25 16:01 | 11/17/25 | PTGX | Protagonist Therapeutics, Inc | DE | Health | Drug | Pharmaceutical Preparations | Molina Arturo Md | CA | O | Chief Me | 6 | S.dm | -4,549 | 50.37 | 0 | -90 | | 84 | D | | | | | | | | | | | | | | |
11/19/25 16:01 | 11/17/25 | GALT | Galectin Therapeutics Inc | NV | Health | Drug | Pharmaceutical Preparations | Callicutt Jack W | GA | O | CFO | 6 | S.dm | -803 | 4.87 | 0 | -165 | | 15 | D | | | | | | | | | | | | | | |
11/18/25 19:28 | 11/17/25 | BBIO | Bridgebio Pharma, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Trimarchi Thomas | CA | O | P,CFO | 3 | S | -4,087 | 53.41 | 0 | -77 | | 463 | D | | | | | | | | | | | | | | |
11/18/25 19:04 | 11/17/25 | DAWN | Day One Biopharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Dubow Adam | CA | O | GC,Secre | 6 | S.d | -239 | 9.85 | 0 | -24 | | 63 | D | | | | | | | | | | | | | | |
11/18/25 19:02 | 11/17/25 | DAWN | Day One Biopharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | York Charles N II | CA | O | COO,CFO | 6 | S.d | -214 | 9.72 | 0 | -22 | | 295 | D | | | | | | | | | | | | | | |
11/18/25 19:00 | 11/17/25 | DAWN | Day One Biopharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Merendino Lauren | CA | O | Chief Co | 3 | S.d | -83 | 7.29 | 0 | -11 | | 51 | D | | | | | | | | | | | | | | |
11/18/25 18:59 | 11/17/25 | DAWN | Day One Biopharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Bender Jeremy | CA | DO | CEO | 6 | S.d | -771 | 9.73 | 0 | -79 | | 1,786 | D | | | | | | | | | | | | | | |
11/18/25 18:39 | 11/14/25 | NATR | Natures Sunshine Products Inc | UT | Health | Drug | Pharmaceutical Preparations | Brower Nathan G | UT | O | EVP,GC | 2 | S | -244 | 17.72 | 0 | -14 | | 48 | D | | | | | | | | | | | | | | |
11/18/25 16:36 | 11/14/25 | TRDA | Entrada Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Parmar Kush | CA | DT | | 3 | S.m | -2,829 | 8.04 | 0 | -352 | | 4,283 | I | | | | | | | | | | | | | | |
11/18/25 16:34 | 7/9/25 | TRDA | Entrada Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | 5Am Ventures V, L.P. | CA | T | | 3 | S.m | -2,829 | 8.04 | 0 | -352 | | 4,283 | M | | | | | | | | | | | | | | |
11/18/25 16:30 | 11/15/25 | MCRB | Seres Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Young Teresa L. | MA | O | See Rema | 8 | S.d | -52 | 1.55 | 0 | -33 | | 98 | D | | | | | | | | | | | | | | |
11/18/25 16:30 | 11/15/25 | MCRB | Seres Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Shaff Eric D. | MA | D | | 7 | S.d | -29 | 1.06 | 0 | -27 | | 192 | D | | | | | | | | | | | | | | |
11/18/25 16:30 | 11/15/25 | MCRB | Seres Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Desrosier Thomas | MA | O | See Rema | 7 | S.d | -11 | 1.02 | 0 | -11 | | 142 | D | | | | | | | | | | | | | | |
11/18/25 16:30 | 11/15/25 | MCRB | Seres Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Henn Matthew R | MA | O | See Rema | 7 | S.d | -31 | 2.75 | 0 | -11 | | 84 | D | | | | | | | | | | | | | | |
11/18/25 16:27 | 9/4/25 | RAPP | Rapport Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Ceesay Abraham | MA | DO | CEO | 4 | S | -2,632 | 26.16 | 0 | -101 | | 722 | D | | | | | | | | | | | | | | |
11/18/25 16:26 | 11/18/25 | RMTI | Rockwell Medical, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Cooper John G | MI | D | | 1 | S | -4 | 0.8701 | 0 | -5 | | 140 | D | | | | | | | | | | | | | | |
11/18/25 16:24 | 11/17/25 | RAPP | Rapport Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Bredt David | MA | O | Chief Sc | 9 | S | -1,234 | 16.13 | 0 | -77 | | 469 | D | | | | | | | | | | | | | | |
11/18/25 16:21 | 11/17/25 | INSM | Insmed Inc | VA | Health | Drug | Pharmaceutical Preparations | Lee Leo | NJ | D | | 1 | S | -14,692 | 195.90 | 0 | -75 | | 55 | D | | | | | | | | | | | | | | |
11/18/25 16:18 | 8/15/25 | CNTA | Centessa Pharmaceuticals Plc | X0 | Health | Drug | Pharmaceutical Preparations | Hussain Iqbal J | X0 | O | GC | 13 | S.dm | -3,278 | 17.84 | 0 | -184 | | 131 | D | | | | | | | | | | | | | | |
11/18/25 16:17 | 2/3/25 | CNTA | Centessa Pharmaceuticals Plc | X0 | Health | Drug | Pharmaceutical Preparations | Bush Tia L | X0 | O | Chief Te | 6 | S.dm | -4,709 | 23.17 | 0 | -203 | | 148 | D | | | | | | | | | | | | | | |
11/18/25 10:05 | 11/17/25 | APLS | Apellis Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Watson David O. | MA | O | GC | 13 | S | -1,843 | 25.69 | 0 | -72 | | 228 | D | | | | | | | | | | | | | | |
11/17/25 19:56 | 11/13/25 | ARQT | Arcutis Biotherapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Krishnamohan Neha | CA | D | | 1 | S.d | -939 | 23.20 | 0 | -41 | | 22 | D | | | | | | | | | | | | | | |
11/17/25 18:01 | 11/13/25 | ANIP | Ani Pharmaceuticals Inc | DE | Health | Drug | Pharmaceutical Preparations | Walsh Patrick D | MN | D | | 2 | S | -1,552 | 87.99 | 0 | -18 | | 70 | D | | | | | | | | | | | | | | |
11/17/25 17:58 | 11/13/25 | XERS | Xeris Biopharma Holdings, Inc. | | Health | Drug | Pharmaceutical Preparations | Shannon John Patrick Jr | IL | DO | See Rema | 1 | S.d | -173 | 7.46 | 0 | -23 | | 2,730 | D | | | | | | | | | | | | | | |
11/17/25 17:52 | 9/3/25 | ROIV | Roivant Sciences Ltd. | D0 | Health | Drug | Pharmaceutical Preparations | Ramaswamy Vivek | DC | T | | 5 | S.m | -92,065 | 14.34 | 0 | -6,420 | | 52,532 | D | | | | | | | | | | | | | | |
11/17/25 16:16 | 11/13/25 | AMPH | Amphastar Pharmaceuticals, Inc. | | Health | Drug | Pharmaceutical Preparations | Petersen Floyd F. | CA | D | | 11 | S.d | -712 | 28.86 | 0 | -25 | | 78 | D | | | | | | | | | | | | | | |
11/17/25 16:12 | 11/13/25 | VRTX | Vertex Pharmaceuticals Inc / Ma | MA | Health | Drug | Pharmaceutical Preparations | Leiden Jeffrey M | MA | DO | Exec CB | 2 | S.dm | -34,181 | 443.47 | 0 | -77 | | 24 | D | | | | | | | | | | | | | | |
11/17/25 16:05 | 11/14/25 | AVTX | Avalo Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Goldman Jonathan | PA | D | | 1 | S.d | -163 | 14.33 | 0 | -11 | -100 | 0 | D | | | | | | | | | | | | | | |
11/14/25 21:00 | 11/13/25 | DNTH | Dianthus Therapeutics, Inc. /De/ | DE | Health | Drug | Pharmaceutical Preparations | Randhawa Simrat | NY | O | EVP,Head | 1 | S.dm | -7,380 | 37.55 | 0 | -197 | | 4 | D | | | | | | | | | | | | | | |
11/14/25 21:00 | 11/13/25 | WVE | Wave Life Sciences Ltd. | U0 | Health | Drug | Pharmaceutical Preparations | Rawcliffe Adrian | MA | D | | 1 | S | -109 | 6.79 | 0 | -16 | | 13 | D | | | | | | | | | | | | | | |
11/14/25 20:00 | 11/14/25 | KURA | Kura Oncology, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Bair Teresa Brophy | CA | O | GC | 4 | S | -244 | 9.22 | 0 | -26 | | 188 | D | | | | | | | | | | | | | | |
11/14/25 20:00 | 11/14/25 | MNKD | Mannkind Corp | DE | Health | Drug | Pharmaceutical Preparations | Singh Sanjay R | CT | O | EVP Tech | 1 | S | -94 | 5.03 | 0 | -19 | | 455 | D | | | | | | | | | | | | | | |
11/14/25 20:00 | 11/14/25 | KURA | Kura Oncology, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Powl Brian T. | CA | O | Chief Co | 3 | S | -191 | 9.88 | 0 | -19 | | 140 | D | | | | | | | | | | | | | | |